Lymphoma Clinical Trial
Official title:
Analysis of Dendritic Phenotype and Function of Patients Receiving VEGF-Trap on VGFT-ST-0202
RATIONALE: Studying the dendritic cells in samples of blood from patients with cancer
receiving aflibercept may help doctors learn about the effect of aflibercept on dendritic
cells.
PURPOSE: This laboratory study is evaluating dendritic cells in patients with advanced solid
tumors or non-Hodgkin lymphoma receiving aflibercept on clinical trial VGFT-ST-0202.
OBJECTIVES:
- Evaluate the effect of in vivo aflibercept on the presence of different populations of
dendritic cells (DC) and immature cells (ImC) in the peripheral blood of cancer
patients by characterizing the time course (kinetics) of the improvement in antigen
presenting cell (APC) phenotype (decline in DC/ImC ratio) occurring early and late
after aflibercept administration.
- Evaluate the effect of aflibercept administration on DC function based on ability to
stimulate antigen specific proliferative (allogeneic and tetanus toxoid) and cytolytic
T cell responses (influenza) by characterizing the time course (kinetics) of the
improvement in APC function occurring early and late after aflibercept administration.
- Explore the relationship of baseline aflibercept level and host APC phenotype.
OUTLINE: This is a multicenter study.
Patients undergo phlebotomy and blood collection at baseline and on days 15, 29, and 57.
Samples are analyzed for dendritic cell phenotype, subpopulations, maturation status, and
function in terms of ability to activate autologous T cells.
;
Observational Model: Case-Only, Time Perspective: Prospective
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