Lymphoma Clinical Trial
Official title:
Pilot Study of Pegylated Interferon-Alfa 2b in Combination With PUVA Therapy in Cutaneous T-Cell Lymphoma
RATIONALE: PEG-interferon alfa-2b may interfere with the growth of cancer cells and slow the
growth of mycosis fungoides/Sezary syndrome. Ultraviolet light therapy uses a drug, such as
psoralen, that is absorbed by cancer cells. The drug becomes active when it is exposed to
ultraviolet light. When the drug is active, cancer cells are killed. Giving PEG-interferon
alfa-2b together with ultraviolet light therapy may kill more cancer cell.
PURPOSE: This is a pilot study of dose-escalating pegylated IFN-α-2b and PUVA or NB-UVB. The
purpose is to study the side effects and best dose of PEG-interferon alfa-2b to be given
together with ultraviolet light therapy in patients with stage IB, stage II, stage III, or
stage IVA mycosis fungoides/Sezary syndrome (CTCL).
Patients receive PEG-interferon alfa-2b subcutaneously once weekly for 12 months in the
absence of disease progression or unacceptable toxicity. Patients also receive UV light
therapy (either PUVA or NB-UVB).
Health-related quality of life is assessed periodically using the FACT-BRM, FACT-G, and
FACT-CTCL questionnaires.
After completion of study therapy, patients are followed for 1 year.
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