Lymphoma Clinical Trial
Official title:
A Phase II Study of Vorinostat (Suberoylanilide Hydroxamic Acid) Plus Rituximab in Indolent Non-Hodgkin's Lymphoma
RATIONALE: Vorinostat may stop the growth of cancer cells by blocking some of the enzymes
needed for cell growth. Monoclonal antibodies, such as rituximab, can block cancer growth in
different ways. Some block the ability of cancer cells to grow and spread. Others find cancer
cells and help kill them or carry cancer-killing substances to them. Giving vorinostat
together with rituximab may kill more cancer cells.
PURPOSE: This phase II trial is studying the side effects of giving vorinostat together with
rituximab and to see how well it works in treating patients with indolent non-Hodgkin
lymphoma.
OBJECTIVES:
- To evaluate the anti-tumor activity of vorinostat and rituximab, in terms of objective
response rate, time to progression, and survival, in patients with indolent non-Hodgkin
lymphoma.
- To assess the toxicity profile of this regimen in these patients.
OUTLINE: Patients receive oral vorinostat twice daily on days 1-14 and rituximab IV on day 1.
Treatment repeats every 21 days in the absence of disease progression or unacceptable
toxicity.
After completion of study treatment, patients are followed periodically.
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