Lymphoma Clinical Trial
Official title:
A Randomized Phase II Trial of Amifostine for Head and Neck Irradiation in Lymphoma
The purpose of this study is determine the effects (good and bad) amifostine has on radiation-induced side effects of lymphoma treatment.
Patients will be randomized into one of two study groups. One study group will receive
amifostine prior to daily radiation therapy and the other group will receive radiation
therapy alone.
Amifostine will be administered 30-60 minutes prior to radiation treatment. Vital signs will
be monitored 5 minutes and 15 minutes after amifostine injection as well as immediately
following radiation treatment.
Patients will also complete a quality-of-life questionnaire on the first and last day of
radiation treatment. Follow-up questionnaires will be done at follow-up visits 1 month, 3
months, 6 months, 12 months, 18 months and 24 months after completion of radiation therapy.
Patients will be removed from the study if they develop an allergic reaction to amifostine.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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