Lymphoma Clinical Trial
Official title:
Characterization of Serum Proteomic Patterns in Neoplastic and Inflammatory Skin Disease
RATIONALE: The presence of specific serum proteins may allow a doctor to determine if a
patient has mycosis fungoides/cutaneous T-cell lymphoma.
PURPOSE: This clinical trial is studying how well blood protein analysis detects mycosis
fungoides/cutaneous T-cell lymphoma.
OBJECTIVES:
- Determine whether computer-assisted, higher-order analysis of participant low molecular
weight serum proteins can detect distinctive proteomic patterns in participants with
normal skin vs mycosis fungoides/cutaneous T-cell lymphoma vs psoriasis.
- Determine whether these proteomic patterns can distinguish between various stages of
cutaneous T-cell lymphoma.
OUTLINE: This is a pilot study.
Participants complete a general and skin health questionnaire and undergo a whole-body skin
examination. Blood samples are taken and analyzed for low molecular weight serum proteins by
mass spectroscopy.
PROJECTED ACCRUAL: A total of 141-423 participants (47-94 each of healthy volunteers,
psoriasis patients, and T3 cutaneous T-cell lymphoma patients and 141 T1, T2, and T4 mycosis
fungoides patients) will be accrued for this study within 3 years.
;
Primary Purpose: Diagnostic
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