Lymphoma Clinical Trial
Official title:
Rituximab Anti-CD20 Monoclonal Antibody and Dexamethasone in the Treatment of Relapsed Indolent Lymphoma
Verified date | August 2015 |
Source | Hoag Memorial Hospital Presbyterian |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Interventional |
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver
tumor-killing substances to them without harming normal cells. Combining the monoclonal
antibody rituximab with dexamethasone may kill more cancer cells.
PURPOSE: Phase II trial to study the effectiveness of rituximab and dexamethasone in
treating patients with recurrent or refractory indolent non-Hodgkin's lymphoma.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | January 2000 |
Est. primary completion date | January 2000 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
DISEASE CHARACTERISTICS: Histologically proven stage III or IV, recurrent or refractory,
indolent B cell non-Hodgkin's lymphoma of the following types: Working Group Formulation A
(small cell lymphocytic) Working Group Formulation B, C, and D (follicular) Must have
relapsed after prior chemotherapy At least 1 lymph node or visceral lesion at least 2 cm
in diameter PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: Not specified Hematopoietic: Lymphocyte count less than 5,000/mm3 Hepatic: Not specified Renal: Not specified Other: Not pregnant or nursing Fertile patients must use effective contraception No active infection HIV negative No hepatitis B or C No concurrent life threatening condition PRIOR CONCURRENT THERAPY: Biologic therapy: No prior monoclonal antibody therapy for lymphoma (e.g., rituximab) Chemotherapy: See Disease Characteristics Endocrine therapy: No other concurrent corticosteroids and/or epinephrine (unless anaphylactic shock) Radiotherapy: Not specified Surgery: Not specified |
Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | Cancer Care Center for Southern Indiana | Bloomington | Indiana |
United States | St. Joseph Regional Cancer Center | Bryan | Texas |
United States | Hoag Memorial Hospital Presbyterian | Newport Beach | California |
Lead Sponsor | Collaborator |
---|---|
Hoag Memorial Hospital Presbyterian | Cancer Biotherapy Research Group |
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