Lymphoma Clinical Trial
Official title:
Vaccination of Lymphoma Patients With Dendritic Cell-lymphoma Cell Hybrids and Dendritic Cells Pulsed With Tumor Lysates
RATIONALE: Biological therapies, such as a dendritic cell vaccine made with a patient's
cancer cells, may stimulate the immune system in different ways and stop cancer cells from
growing.
PURPOSE: This phase I/II trial is studying the side effects of dendritic cell vaccine and to
see how well it works in treating patients with indolent B-cell lymphoma or multiple myeloma.
OBJECTIVES:
- Evaluation of feasibility of dendritic cell (DC)-based vaccination program using
autologous tumor cells and/or lysates in patients with indolent B cell lymphomas or
multiple myeloma as an adjuvant therapy to induce immune response in remission after
cytoreductive treatment.
- Evaluation of the immune response of patients treated with this regimen.
- Evaluation the progression-free survival of patients treated this regimen.
- Evaluate the adverse events of this regimen in these patients.
OUTLINE: Patients receive intranodal (under ultrasound guidance) or subcutaneous vaccinations
of adjuvant electrofusion hybrids of autologous dendritic cells (DC) with autologous lymphoma
cells, electrofusion hybrids of allogeneic DC with autologous lymphoma cells, and/or
autologous DC pulsed with autologous tumor lysate cells in weeks 0, 2, 4, 8, 12, 18, 26, and
50.
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