Lymphoma Clinical Trial
Official title:
Health-Related Outcomes For Hodgkin's Disease Survivors
RATIONALE: Assessing the long-term effects of cancer treatment in cancer survivors may help
improve the ability to plan effective treatment and follow-up care.
PURPOSE: This clinical trial is studying the long-term effects of treatment in patients who
were previously treated for childhood Hodgkin's lymphoma.
OBJECTIVES:
- Determine the cumulative incidence and characterize the spectrum of selected adverse
physiologic and psychosocial outcomes, using self-report and clinical evaluation, in
patients previously treated for childhood Hodgkin's lymphoma.
- Compare the cumulative incidence and spectrum of self-reported adverse outcomes of these
patients, using data collected at a comparable time period after diagnosis, with
Hodgkin's lymphoma survivors from the Childhood Cancer Survivor Study (CCSS).
- Compare self-reported health-related outcomes with outcomes detected by clinical
evaluation and medical record review of each group of patients.
OUTLINE: This is a cohort, cross-sectional, multicenter study.
- Contemporary group: Patients complete a self-report of long-term outcomes questionnaire
and a comprehensive psychosocial questionnaire. A medical record review is then
performed. Patients then undergo a comprehensive risk-based clinical evaluation with
specific examinations and studies based upon the Children's Oncology Group Late Effects
Screening Guidelines and the patients' specific therapeutic exposures.
- Childhood Cancer Survivor Study (CCSS) group: Patients undergo a telephone interview and
have medical records reviewed to validate select self-reported long-term outcomes.
Patient replies from the baseline CCSS questionnaire (which was completed at certain
timepoints after diagnosis) are reviewed for targeted long-term outcomes.
PROJECTED ACCRUAL: Approximately 1,000 patients will be accrued for this study.
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