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Lymphoma clinical trials

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NCT ID: NCT03648372 Terminated - Lymphoma Clinical Trials

A Study of TAK-981 in People With Advanced Solid Tumors or Cancers in the Immune System

Start date: October 1, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This study is in 2 parts. The main aims of the 1st part of the study are to check if people with advanced solid tumors or cancers in the immune system (lymphomas) have side effects from TAK-981, and to check how much TAK-981 they can receive without getting side effects from it. The main aims of the 2nd part of the study are to learn if the condition of people with specific cancers improves after treatment with TAK-981. Another aim is to check for side effects from TAK-981. In the 1st part of the study, participants will receive TAK-981. In the 2nd part of the study, participants with specific tumor types will receive TAK-981 at the recommended phase 2 dose determined during the 1st part of the study. In both parts of the study, participants can receive TAK-981 for up to 1 year or longer if their condition stays improved. Participants will receive TAK-981 through vein.

NCT ID: NCT03647124 Recruiting - Clinical trials for Lymphoma, Mantle-Cell

A Study to Evaluate the Relationship of Lenalidomide With Tumor Flare Reaction and High Tumor Burden in Participants With Relapsed or Refractory Mantle Cell Lymphoma

Start date: March 13, 2019
Phase:
Study type: Observational

The purpose of this study is to investigate and characterize the association of lenalidomide with tumor flare reaction and high tumor burden in participants with relapsed or refractory mantle cell lymphoma.

NCT ID: NCT03647072 Recruiting - Lymphoma Clinical Trials

PPI Versus Histamine Antagnists as Adjuvant to Chemotherapy

Start date: August 1, 2018
Phase: Phase 3
Study type: Interventional

The study is a Comparative Clinical and Biochemical Study Evaluating the effect of Proton Pump I nhibitors versus histamine 2 Receptor antagonists as an adjuvant with chemotherapy in patients with Non-hodgkin Lymphoma.

NCT ID: NCT03646422 Recruiting - Lymphoma, B-Cell Clinical Trials

AEDV Registry of Primary Cutaneous Lymphoma

Start date: September 1, 2016
Phase:
Study type: Observational [Patient Registry]

Registry of patients with Primary Cutaneous Lymphoma seen at participating centers in Spain. The registry will identify patients with this disease and includes information about stage, diagnostic and therapeutic interventions and willingness to participate in further studies.

NCT ID: NCT03646123 Active, not recruiting - Hodgkin Lymphoma Clinical Trials

Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma

Start date: January 28, 2019
Phase: Phase 2
Study type: Interventional

This trial will study two treatment combinations for classical Hodgkin lymphoma (cHL). This trial will find out if these two treatment combinations work to treat cHL. It will also find out what side effects occur. A side effect is anything the drug does besides treating cancer. This study will have three parts (Parts A, B, and C). The drugs used in Part A are a combination of targeted anticancer drug (brentuximab vedotin) and three chemotherapy drugs (doxorubicin, vinblastine, and dacarbazine). These four drugs are called "A+AVD." Participants will be treated with granulocyte colony stimulating factor (G-CSF) following every dose of A+AVD for 6 cycles of treatment (12 doses). Part A will look at whether the A+AVD drug combination reduces the number of participants who experience the side effect of febrile neutropenia. Febrile neutropenia is a very low white blood cell count and a fever, which can be life threatening. Parts B and C will use drug combination of brentuximab vedotin, plus nivolumab, doxorubicin, and dacarbazine. These four drugs are called "AN+AD." Parts B and C will study how well the drugs work to treat cHL and what side effects they cause.

NCT ID: NCT03645395 Terminated - Clinical trials for Non-hodgkin Lymphoma

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Multiple Dose Regimens of MT-3724 With Lenalidomide for the Treatment of Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (MT-3724_NHL_003)

Start date: April 8, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety and tolerability of MT-3724 in combination with Lenalidomide in participants with relapsed or refractory B-Cell NHL.

NCT ID: NCT03639324 Withdrawn - Clinical trials for Chronic Lymphocytic Leukemia

Rituximab, Idelalisib, and Venetoclax in Relapsed/Refractory CLL/SLL

RIVe-CLL/SLL
Start date: October 2, 2020
Phase: Phase 1
Study type: Interventional

To determine the recommended phase 2 dose (RP2D) of idelalisib and venetoclax in combination with rituximab in patients with relapsed or refractory Chronic lymphocytic leukemia/ Small lymphocytic lymphoma (CLL/SLL) following a lead-in period with idelalisib and rituximab

NCT ID: NCT03639181 Recruiting - Clinical trials for B-cell Non-Hodgkin's Lymphoma

Clinical Trial in Chinese Patients of B-cell Non-Hodgkin's Lymphoma(GB226)

Start date: October 15, 2018
Phase: Phase 2
Study type: Interventional

An open-label, single-arm, phase II clinical study of anti-PD-1 antibody GB226 in treatment of recurrent or refractory B-cell non-Hodgkin's lymphoma (B-NHL)

NCT ID: NCT03638206 Recruiting - Colorectal Cancer Clinical Trials

Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies

Start date: March 1, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This is a single arm, open-label, uni-center, phase I-II study to evaluate the safety and effectiveness of CAR-T/TCR-T cell immunotherapy in treating with different malignancies patients.

NCT ID: NCT03636503 Active, not recruiting - Follicular Lymphoma Clinical Trials

RITUXIMAB + IMMUNOTHERAPY IN FOLLICULAR LYMPHOMA

Start date: October 30, 2018
Phase: Phase 1
Study type: Interventional

This research study is studying several new investigational drug combinations as a possible treatment for follicular lymphoma. The drugs involved are: - Rituximab - Utomilumab - Avelumab