Lymphoma, Large B-Cell, Diffuse Clinical Trial
Official title:
Prospective Cohort Study for Genomic Evaluation in Patients With Diffuse Large B Cell Lymphoma After First Relapse/Progression
DLBCL has the highest frequency out of all lymphoid malignancies. With the recent development of antitumor agents targeting intracellular/extracellular cell signaling pathways, patients have access to various treatment options after relapse. Therefore, for the purpose of developing effective treatment strategies, large-scale genomic data accumulation is necessary to understand the mechanism of relapse and refractory state of DLBCL.
- To understand the mechanism of relapse by genome sequencing with tissues/blood obtained
at diagnosis and relapse in patients with diffuse B cell lymphoma who relapsed after
standard chemotherapy, to evaluate their response and survival following a salvage
therapy depending on the genomic sequencing results, and to understand the prognostic or
predictive value of genomic mutation.
- To understand the predictive value of genetic information with regard to the response to
salvage chemotherapy and survival outcome in patients with newly diagnosed/relapsed or
refractory large B cell lymphoma
- To determine the association between gene mutation, treatment response and prognosis in
relapsed/refractory diffuse large B cell lymphoma (DLBCL), and to develop a clinically
applicable platform by establishing a genetic data register based on prospective studies
;
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