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MESA Treatment for NK/T Cell Lymphoma — MTN  

Lymphoma, Extranodal NK-T-Cell Clinical Trial

Official title:
Phase II Study of MESA Chemotherapy in Patients With Natural Killer/T Cell Lymphoma

Clinical Trial Summary

Study on the efficacy and safety of MESA chemotherapy for treating NK/T cell lymphoma

Clinical Trial Description

Extranodal natural killer (NK)/T-cell lymphoma (ENKTL), nasal type, is a distinct and heterogeneous histopathologic subtype of non-Hodgkin lymphoma (NHL), accounting for 5%~10%. The frequency of ENKTL among NHL patients is significantly higher in Asia than in Western countries. Despite radiotherapy and chemotherapy, the prognosis for ENKTL patients is poor, with 5-year median survival time for primary nasal site was 5 years, for non-nasal extranodal sites 6 months. ENKTL is so aggressive and has high mortality rate and till now there is no standard therapy. In recent years SMILE chemotherapy has clinical efficacy and is one of first line therapy for ENKTL. However it is apparent that this regimen is extremely toxic with grade 4 neutropenia especially for Asian patients. On these grounds, new therapy MESA is used for Asian patients with ENKTL in order to achieve good efficacy and safety. ;

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01933282
Study type Interventional
Source Fourth Military Medical University
Contact RONG LIANG, professor
Phone 86 13384933870
Email rongliang1017@gmail.com
Status Recruiting
Phase Phase 2
Start date January 2013
Completion date January 2015
View Details
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