Effects of Extracorporeal Shock Wave Therapy & Pulse Electromagnetic Field

Status Recruiting

Clinical Trial Summary

Lymphedema occurs not only in patients with breast cancer and gynecological cancers but also in those where lymphatic drainage is obstructed. Accumulation of lymphatic fluid within tissues results in limb swelling. Additionally, proteins present in lymphatic fluid might lead to fibrosis within tissues, causing various challenges for patients. The changes in volume and weight can significantly impact daily life activities such as eating, brushing teeth, and other routine tasks. Furthermore, it can lead to clothing difficulties and provoke unwanted attention due to aesthetic concerns. Currently, there is no definitive treatment for lymphedema. However, prospective research has shown promising results in applying extracorporeal shock wave therapy (ESWT), originally used for musculoskeletal disorders like plantar fasciitis, tennis elbow, frozen shoulder, and non-union fractures, to lymphedema patients. Similarly, Pulse Electromagnetic Field Therapy (PEMFT), widely used for pain management and muscle strengthening, has the potential for treating lymphedema as it can enhance blood circulation and stimulate muscle contractions. This research project aims to explore the effectiveness and sustainability of using ESWT and PEMFT for lymphedema patients. By applying these therapies to lymphedema patients, this study aims to evaluate their treatment outcomes and long-term effects.

Clinical Trial Description

There is currently no cure for lymphedema. Literature review revealed extracorporeal shock wave therapy (previously applied to soft tissue diseases such as plantar fasciitis, tennis elbow, frozen shoulders, and poor fracture healing) showed positive therapeutic effect for patients with lymphedema. Another widely used therapy for pain treatment and muscle strengthening is Pulse Electromagnetic Field Therapy (PEMFT), which has the potential to be used in the treatment of lymphedema due to its ability to increase blood circulation and stimulate muscle contractions. This study design to evaluate the effect of extracorporeal shock wave therapy on patients with lymphedema, and further explore its therapeutic effect. ;

Study Design

Related Conditions & MeSH terms

Lymphedema

Clinical Trial Details

NCT number	NCT06041958
Study type	Interventional
Source	Kaohsiung Veterans General Hospital.
Contact	Zheng Yu Hoe, MD.,PhD.
Phone	+886935517631
Email	jhoe@vghks.gov.tw
Status	Recruiting
Phase	N/A
Start date	October 8, 2021
Completion date	December 31, 2025

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05507346` - A Clinical Study to Evaluate the Effectiveness of a Novel Portable Non-Pneumatic Active Compression Device vs. an Advanced Pneumatic Compression Device for Treating Lower Extremity Lymphedema	N/A
Completed	`NCT06067880` - Surgical Intervention and Lymphatic Diseases.
Active, not recruiting	`NCT04797390` - A Study Evaluating an Advanced Pneumatic Compression Device Versus Usual Care for Treatment of Head and Neck Lymphedema	N/A
Completed	`NCT02676752` - Skin/Soft Tissue Elasticity in Head and Neck Cancer Survivors With Lymphedema and Fibrosis
Completed	`NCT06323200` - Lymphedema Duration on Lymphatic Vessel Quality and Outcomes After LVA
Completed	`NCT02506530` - Treatment Pathway of Patients Suffering From a Breast Cancer Related Lymphoedema	N/A
Completed	`NCT02253186` - Clinical Study to Assess Safety and Efficacy of a New Armsleeve in the Management of Arm Lymphoedema	N/A
Terminated	`NCT02020837` - A Pilot Study Assessing the Effect of Lymphaticovenous Micro-Anastomosis in the Treatment of Postmastectomy Lymphedema	Early Phase 1
Recruiting	`NCT01318785` - Therapeutical Assessment of Compression Armsleeves for Lymphatic Indications	Phase 2
Enrolling by invitation	`NCT02375165` - Biomarkers for the Detection of Lymphatic Insufficiency
Completed	`NCT01112189` - Use of Stem Cells in Lymphedema Post Mastectomy	Phase 1/Phase 2
Completed	`NCT02308488` - Study of Prone Accelerated Breast And Nodal IMRT	N/A
Completed	`NCT00852930` - Low Level Laser Treatment and Breast Cancer Related Lymphedema	Phase 4
Completed	`NCT00743314` - Single-Photon Emission Computed Tomography, Computed Tomography Lymphoscintigraphy, and Intensity-Modulated Radiation Therapy in Treating Patients Who Have Undergone Surgery for Stage I or Stage II Breast Cancer	Early Phase 1
Recruiting	`NCT06237907` - Pyroptosis and Ferroptosis in the Pathophysiology of Lymphedema
Terminated	`NCT01580800` - National Breast Cancer and Lymphedema Registry
Suspended	`NCT05366699` - LYMPHA Procedure for the Prevention of Lymphedema After Axillary Lymphadenectomy	N/A
Completed	`NCT06249360` - Lymphatic System Reflux After Lymphatic Operation
Completed	`NCT06220903` - The Effect of Complex Decongestive Therapy in Patients With Lymphedema	N/A
Terminated	`NCT02923037` - Hatha Yoga in Breast Cancer Survivors	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Effects of Extracorporeal Shock Wave Therapy and Pulse Electromagnetic Field Therapy on Lymphoedema

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms