Spontaneous Antigenemia in Loiasis

Status Active, not recruiting

Clinical Trial Summary

This prospective study will enroll and follow 60 loiasis patients with high worm burden to monitor the spontaneous release of filarial antigen in peripheral blood. This study will define the cross-reactive antigen profile of persons with spontaneous loiasis antigenemia, and determine whether it varies with time.

Clinical Trial Description

Global efforts to eradicate lymphatic filariasis (LF) depend on rapid diagnostic tests (RDTs) that detect Wuchereria bancrofti circulating filarial antigen but these tests are unreliable in African nations where Loa loa is co-endemic because they yield false-positive results in some individuals with loiasis. The goals of this project are to define the cross-reactive antigen profile of persons with spontaneous antigenemia, how it varies over time, and to determine which L. loa antigens in cross-reactive sera best distinguish loiasis cross-reactivity from LF.

This prospective study will prospectively enroll 50 adults who presented with cross-reactive antigenemia at screening and 10 negative controls. Participants will followed for one year and tested every three months for persistence of antigenemia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04258670
Study type	Observational [Patient Registry]
Source	Washington University School of Medicine
Contact
Status	Active, not recruiting
Phase
Start date	January 23, 2020
Completion date	December 31, 2021

View Details

See also
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