Lupus Nephritis Clinical Trial
Official title:
T Regulatory Cells in Lupus Nephritis
- To study the role FoxP3-positive T regulatory cells in the pathogenesis of Lupus Nephritis, and determine the factors associated with levels of T regs . - To compare the functional capacity of T regs in LN and in normal individuals.
Status | Not yet recruiting |
Enrollment | 65 |
Est. completion date | August 1, 2025 |
Est. primary completion date | July 1, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 85 Years |
Eligibility | Inclusion Criteria: adults both genders clinical diagnosis of lupus nephritis Exclusion Criteria: patients diagnosed with other renal pathologies, e.g. diabetic kidney disease |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Doglio M, Alexander T, Del Papa N, Snowden JA, Greco R; Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT). New insights in systemic lupus erythematosus: From regulatory T cells to CAR-T-cell strat — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | FoxP3 between groups | mean difference of FoxP3 between groups. | baseline | |
Primary | Association of FoxP3 and activity index | correlation between level of FoxP3 and activity index in the group with active LN. | baseline | |
Primary | Tregs in normal and lupus participants | mean difference of suppression capacity of Tregs between normal participants and patients with active LN. | baseline |
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