Fibroblast Activating Protein Inhibitor PET Imaging in Lupus Nephritis

Status Recruiting

Clinical Trial Summary

Abnormal high expression of fibroblast activating protein (FAP) has been found in inflammatory reactions and benign fibrosis tissue. Autoimmune nephropathy such as lupus nephritis (LN) can lead to tubular atrophy and excessive deposition of extracellular matrix, which may be accompanied by abnormally increased expression of activated FAP in kidney tissue, and lead to renal fibrosis and long-term renal failure. This makes 68Ga-labeled FAP inhibitor (FAPI) positron emission tomography (PET) imaging the potential to early assess disease severity, predict disease progress and aid treatment planning in patients with LN. Compared to renal pathological puncture, 68Ga-FAPI PET is a new tool for non-invasive, repeatable assessment of renal fibrotic activation.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05845151
Study type	Interventional
Source	Ruijin Hospital
Contact	Hui Shi, Dr.
Phone	0086 21 64370045
Email	shihui_sjtu@sina.com
Status	Recruiting
Phase	N/A
Start date	May 1, 2021
Completion date	April 30, 2024

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See also
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