Planned Semi-Elective Lung Tx Study

Status Completed

Clinical Trial Summary

In the current practice of lung transplantation, transplants are performed on a 24/7 schedule with a significant amount of procedures occurring overnight in order to minimize organ ischemic time. However, transplantation during the day time may lead to several advantages related to patient safety, including the presence of rested staff performing optimally, larger number of in-house professionals for emergency situations, and professional well-being. Advances and refinements in preservation practices have evolved to show that extended periods of preservation can be achieved without compromising outcome. Based on this, it is hypothesized that the avoidance of nighttime lung transplantation through prolonged pulmonary preservation will lead to at least similar patient outcomes compared to the current practice of 24/7 transplantation. During the period of this study, overnight transplants will be moved to a later start time (earliest 6AM). If lungs meet criteria for direct transplantation, they will be preserved with cold static preservation at 10°C within a special refrigerator. The maximum preservation time from donor cold flush to recipient anesthesia start time will be 12 hours.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Lung Transplantation

Clinical Trial Details

NCT number	NCT04616365
Study type	Interventional
Source	University Health Network, Toronto
Contact
Status	Completed
Phase	N/A
Start date	August 26, 2020
Completion date	April 21, 2023

View Details

See also
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