Pharmacokinetics of Imipenem During Ex Vivo Lung Perfusion (EVLP)

Status Recruiting

Clinical Trial Summary

Ex vivo lung perfusion (EVLP) is an established strategy to evaluate and optimize high-risk donor lungs that would otherwise be rejected for transplantation mainly due to the presence of edema or infection. Extracorporeal circuits may negatively affects pharmacokinetic (PK) of several drugs including antibiotics, thus exposing patients to risk of therapeutic failure or drug toxicity. The investigators set out to examine the concentration of imipenem in lung perfusate and in lung biopsy during EVLP, and its clinical impact.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Lung Transplantation

Clinical Trial Details

NCT number	NCT02670239
Study type	Observational
Source	University of Turin, Italy
Contact	Vito Fanelli, MD, PhD
Phone	0039011633
Email	vito.fanelli@unito.it
Status	Recruiting
Phase	N/A
Start date	May 2014

View Details

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