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Diagnostic and Prognostic Biomarkers of Transplant Dysfunction in the Context of Lung Transplantation — DATACOL  

Lung Transplant; Complications Clinical Trial

Official title:
Diagnostic and Prognostic Biomarkers of Transplant Dysfunction in the Context of Lung Transplantation

Clinical Trial Summary

Transplant results vary considerably from one organ to another. Lung transplantation has poorer long-term outcomes than other solid organ transplants, with a current median post-transplant survival of 6.0 years. Allograft rejection remains the leading cause of morbidity and mortality in all organ groups and is the leading cause of death, accounting for more than 40% of deaths beyond the first year after lung transplantation. Each dysfunctions impacts the fate of the graft and therefore the survival of the recipient. Their early and precise diagnosis is therefore a major issue. The identification of the pathophysiological mechanisms underlying these different subtypes of dysfunction (transcriptomics, polymorphism of target genes of the immune system or tissue repair, cell phenotyping) is an essential step. It can only be done on the basis of a collection of samples linked to a clinical database allowing to contextualize each sample.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04837339
Study type Interventional
Source Hopital Foch
Contact Antoine ROUX, Dr
Phone 0146252635
Email a.roux@hopital-foch.com
Status Recruiting
Phase N/A
Start date March 17, 2022
Completion date March 2037
View Details
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