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Afatinib in Lung Cancer With EGFR Mutation From Circulating Tumor DNA — LiquidLung-A  

Lung Neoplasms Clinical Trial

Official title:
A Phase II, Open-Label, Multicentre Study to Assess the Anti-tumour Activity of Afatinib in Patients With Activating Epidermal Growth Factor Receptor Mutation in Circulating Tumor DNA

Clinical Trial Summary

Treatment efficacy of afatinib will be assessed in patients with lung cancer harboring EGFR mutations which were detected from circulating tumor DNA.

Clinical Trial Description

Obtaining Tumor tissue or cytology samples are not always available in some patients with lung cancer. Recently, studies showed that circulating tumor DNA can be used as a suitable substitute for mutation analysis. The sensitivity of EGFR mutation tests using circulating tumor DNA was reported in the range of 65.7% (10) to 75% (11), with high specificity and positive predictive value. In this trial, treatment efficacy of afatinib will be assessed in patients with NSCLC harboring EGFR mutations which were detected from circulating tumor DNA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02629523
Study type Interventional
Source Chonnam National University Hospital
Contact
Status Completed
Phase Phase 2
Start date June 1, 2016
Completion date May 11, 2020
View Details
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