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Lung Neoplasms clinical trials

View clinical trials related to Lung Neoplasms.

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NCT ID: NCT05933239 Recruiting - Clinical trials for Non-small Cell Lung Cancer

Macrophage Imaging Using Ga-MMR-VHH2 in Lung Cancer Patients

MAGMA
Start date: March 30, 2023
Phase: Phase 2
Study type: Interventional

Phase II study to evaluate the clinical potential of 68GaNOTA-anti-MMR-VHH2 for in vivo imaging of Macrophage Mannose Receptor (MMR)-expressing Macrophages by means of Positron Emission Tomography (PET) in patients with non-small cell lung cancer (NSCLC) planned for surgical resection.

NCT ID: NCT05933044 Completed - Clinical trials for Non-small Cell Lung Cancer

RELEVANCE - RWE Study in Unresectable Non-Small Cell Lung Cancer (Stage III) in Canada

RELEVANCE
Start date: November 19, 2021
Phase:
Study type: Observational

In the RELEVANCE study, we will develop a scalable electronic medical report data capture platform to collect and analyse real-world data in the stage III NSCLC population in Canada across several Canadian cancer centres. Subsequent analyses will examine treatment patterns and clinical outcomes, including overall survival, for these patients, stratified by durvalumab regimen or non-durvalumab regimen during the time of the PACIFIC Patient Support Program.

NCT ID: NCT05932264 Not yet recruiting - Clinical trials for Non-small Cell Lung Cancer

Apatinib and Fluzoparib With or Without Adebrelimab in Previously-treated TP53-mutant Advanced Non-small Cell Lung Cancer

Start date: July 2023
Phase: Phase 2
Study type: Interventional

This is a phase 2, open-label study to evaluate the efficacy and safety of combination of Apatinib and Fluzoparib with or without Adebrelimab in previously-treated TP53-mutant advanced non-small cell lung cancer.

NCT ID: NCT05928299 Recruiting - Lung Cancer Clinical Trials

Integrative Multi-Omics Testing for Immunotherapy Response in Non-Small Cell Lung Cancer

IMOTION
Start date: January 1, 2020
Phase:
Study type: Observational

The objective of this study is to use blood and urine proteomic and metabolomic features to monitor lung cancer immunotherapy response.

NCT ID: NCT05926180 Recruiting - Clinical trials for Non-small Cell Lung Cancer

Assessing the Effect of DZD9008 on the Pharmacokinetics of the Cocktail Probes Representative for CYP3A4, P-gp, BCRP and OATP1B1 in Patients With EGFR or HER2 Mutant Advanced Non-small Cell Lung Cancer (WU-KONG19)

Start date: July 31, 2023
Phase: Phase 1
Study type: Interventional

This study will treat patients with advanced NSCLC who have progressed following prior therapy in order to assess the effect of DZD9008 on exposure of midazolam, digoxin and rosuvastatin, through multiple PK parameters, when administrated as a single dose alone and in combination with DZD9008. Also, it will assess the safety and tolerability of DZD9008 in the presence and absence of co-administration of cocktail probes.

NCT ID: NCT05925751 Recruiting - Clinical trials for Non-small Cell Lung Cancer

Deep Learning Signature for Predicting Complete Pathological Response to Neoadjuvant Chemoimmunotherapy in Non-small Cell Lung Cancer

Start date: May 1, 2023
Phase:
Study type: Observational

The purpose of this study is to evaluate the performance of a CT/PET/ WSI-based deep learning signature for predicting complete pathological response to neoadjuvant chemoimmunotherapy in non-small cell lung cancer

NCT ID: NCT05925738 Recruiting - Clinical trials for Non-small Cell Lung Cancer

Deep Learning Signature for Predicting Aggressive Histological Pattern in Resected Non-small Cell Lung Cancer

Start date: May 1, 2023
Phase:
Study type: Observational

The purpose of this study is to evaluate the performance of a PET/ CT-based deep learning signature for predicting aggressive histological pattern in resected non-small cell lung cancer based on a multicenter prospective cohort.

NCT ID: NCT05925530 Recruiting - Clinical trials for Non-small Cell Lung Cancer

Study to Assess Neoadjuvant Durvalumab (D) and Platinum-Based Chemotherapy (CT), Followed by Either Surgery and Adjuvant D or CRT and Consolidation D, in Resectable or Borderline Resectable Stage IIB-IIIB NSCLC (MDT-BRIDGE)

MDT-BRIDGE
Start date: February 22, 2024
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess efficacy and safety of neoadjuvant durvalumab in combination with platinum-based chemotherapy (CT) given as initial therapy after cancer diagnosis followed by either surgery and adjuvant durvalumab or chemoradiotherapy (CRT) and consolidation durvalumab given alone as further therapy in participants with resectable and borderline resectable stage IIB-IIIB NSCLC.

NCT ID: NCT05924841 Recruiting - Clinical trials for Small Cell Lung Cancer

A Study of BL-B01D1, SI-B003 and BL-B01D1+SI-B003 in Patients With Extensive Stage Small Cell Lung Cancer

Start date: November 10, 2023
Phase: Phase 2
Study type: Interventional

This phase II study is designed to investigate the efficacy and safety of BL-B01D1 monotherapy, SI-B003 monotherapy, and BL-B01D1+SI-B003 combination therapy in patients with extensive-stage small cell lung cancer.

NCT ID: NCT05922345 Recruiting - Clinical trials for Non-small Cell Lung Cancer

Evaluation of the Efficacy and Safety of AL2846 Capsule Combined With TQB2450 Injection Compared to Docetaxel Injection in Advanced Non-small Cell Lung Cancer Patients Who Have Failed With Immunotherapy.

Start date: June 8, 2023
Phase: Phase 3
Study type: Interventional

To investigate the efficacy of AL2846 capsules in combination with TQB2450 injection or Docetaxel injection in patients with advanced NSCLC who have previously failed immune checkpoint inhibitors (anti-PD-1 monoclonal antibody, anti-PD-L1 monoclonal antibody), regardless of new anti-tumor treatment and early termination of treatment.