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Clinical Trial Summary

Create a living biobank of PDOs from Stage I-III lung cancer patients.


Clinical Trial Description

Creation a living biobank of PDOs from Stage I-IV lung cancer patients (n=50). We selected enrollment of at least 50 patients so that they can be risk stratified based on lung tumor type, staging and we plan to store these PDOs in biobank for future experiments. For each patient, tumor specimens will be collected at time of their surgery. No specific therapeutic intervention or treatment is provided as part of this study. 1. Establishment and culture of PDOs from lung cancer tumor specimens. PDOs will be biobanked for future experiments. 2. Lung organoids and CTCs will also be cultured and used to study baseline tumor characteristics using histology, immunohistochemistry, atomic force measurements; as well as, oncogenic signaling pathways and proteomic profile of lung organoids and CTCs derived from lung cancer patients (n>50). 3. Patient demographic information and data to be collected using a patient survey data sheet with treatment and survival history collected at pre-defined time period per the protocol schedule. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03655015
Study type Observational
Source The University of Texas Health Science Center at San Antonio
Contact Josephine Taverna, MD
Phone 210-450-8234
Email tavernaj@uthscsa.edu
Status Recruiting
Phase
Start date October 16, 2018
Completion date December 2029

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