Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function

Lung Function Clinical Trial

Official title:

Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00706277
• Other study ID #: 2007-007161-25
• Status: Completed
• Phase: Phase 4
• First received: June 25, 2008
• Last updated: February 9, 2009
• Start date: June 2008
• Est. completion date: December 2008

Study information

• Verified date: February 2009
• Source: Medical University Innsbruck
• Contact: n/a
• Is FDA regulated: No
• Health authority: Austria: Agency for Health and Food Safety
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to investigate the effects of total intravenous anesthesia (TIVA; propofol, remifentanil) and balanced anesthesia (BAL; induction with propofol and fentanyl; maintenance of anesthesia with sevoflurane and nitrous oxide) on pulmonary function 30 minutes after emergence from the general anesthesia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: December 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• ASA 1-2

• BMI normal

Exclusion Criteria:

• lung disease

• Nicotine abuse

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Lung Function

Intervention

Drug:
• propofol
propofol 2mg/kg for induction of anesthesia; followed by propofol 6 mg/kg/hour
• propofol
propofol 2mg
• remifentanil
remifentanil 0,25mcg/kg/hour
• fentanyl
fentanyl 100mcg
• Sevoflurane/Nitrous Oxide
maintenance of anesthesia with sevoflurane and nitrous oxide

Locations

Country	Name	City	State
Austria	TILAK Hospitals	Innsbruck

Sponsors (1)

Lead Sponsor	Collaborator
Medical University Innsbruck

Country where clinical trial is conducted

Austria, 

References & Publications (3)

Gunnarsson L, Lindberg P, Tokics L, Thorstensson O, Thörne A. Lung function after open versus laparoscopic cholecystectomy. Acta Anaesthesiol Scand. 1995 Apr;39(3):302-6. — View Citation

Natalini G, Franceschetti ME, Pletti C, Recupero D, Lanza G, Bernardini A. Impact of laryngeal mask airway and tracheal tube on pulmonary function during the early postoperative period. Acta Anaesthesiol Scand. 2002 May;46(5):525-8. — View Citation

Regli A, von Ungern-Sternberg BS, Reber A, Schneider MC. Impact of spinal anaesthesia on peri-operative lung volumes in obese and morbidly obese female patients. Anaesthesia. 2006 Mar;61(3):215-21. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	FEV1 forced expiratory volume; FVC forced vital capacity		preoperative, 30 minutes postoperative	No