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DC Combined With ICIs in the Treatment of Advanced Lung Cancer Resistant to ICIs

Lung Cancer Clinical Trial

Official title:
Single-arm, Open, Prospective Clinical Study of Neoantigen-loaded Dendritic Cell Vaccine (Neo-DCVac) Combined With Immune Checkpoint Inhibitors (ICIs) in the Treatment of Advanced Lung Cancer Resistant to ICIs

Clinical Trial Summary

This is a single-center, single-arm, prospective clinical trial to investigate the safety and efficacy of Neo-DCVac combined with ICIs in the treatment of advanced lung cancer resistant to ICIs.

Clinical Trial Description

The study screened patients with PD-1 immunochemotherapy in the first-line treatment regimen, and extracted tumor tissues from patients after PD-1 resistance for neoantigen prediction. During neoantigen screening and vaccine preparation, patients received a second-line regimen (docetaxel) as bridging therapy. After completion of bridging therapy and the patient 's vaccine preparation was successful, the patient started receiving the vaccine combined with ICIs. The completion of 5 vaccine injections was followed by an immunization course. Efficacy was assessed 2 weeks after the end of an immunization course, and if effective (tumor response evaluated as SD/PR/CR), the next cycle of immunotherapy was continued, with subsequent treatments administered every 3 weeks until disease progression or severe intolerance occurred or the patient requested withdrawal, whichever came first. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06329908
Study type Interventional
Source Sichuan University
Contact Zhengyu Ding, MD
Phone 18980601957
Email dingzhenyu@scu.edu.cn
Status Recruiting
Phase Early Phase 1
Start date September 27, 2023
Completion date October 31, 2026
View Details
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