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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05134558
Other study ID # 201912128RIN
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date February 4, 2020
Est. completion date December 31, 2024

Study information

Verified date September 2021
Source National Taiwan University Hospital
Contact Yu-Sen Huang, Md PhD
Phone +886-23123456
Email yusen0814@gmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.


Description:

There has been an increase in the application of radiation therapy in the treatment of lung tumors; however, the associated side effect, called radiation pneumonitis, can significantly reduce lung function and the quality of life of patients, eventually leading to fatal consequences. The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.


Recruitment information / eligibility

Status Recruiting
Enrollment 60
Est. completion date December 31, 2024
Est. primary completion date December 31, 2024
Accepts healthy volunteers No
Gender All
Age group 20 Years to 80 Years
Eligibility Inclusion Criteria: - Patients aged 20-80 years, with lung cancer receiving thoracic radiotherapy in NTUH, from February 2020 to December 2024. Exclusion Criteria: - The age is less than 20 years old or older than 80 years old. - Unstable clinical condition, unable to maintain apnea for 15 second, and history of prior adverse reaction to xenon. - Renal insufficiency patients. - Claustrophobia - Those who are pregnant.

Study Design


Intervention

Radiation:
Xenon-enhanced Ventilation CT-guided Radiotherapy
Xenon-enhanced Ventilation CT-guided Radiotherapy for functional protection of the lung

Locations

Country Name City State
Taiwan National Taiwan University Hospital Taipei

Sponsors (1)

Lead Sponsor Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type Measure Description Time frame Safety issue
Primary Incidence of radiation pneumonia Incidence of radiation pneumonia Within 1 year of radiation therapy
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