| Eligibility |
Inclusion Criteria:
1. Provision of informed consent prior to any study specific procedures
2. SCLC that satisfies one or more of the following conditions; Histologically confirmed
SCLC with documented
1) ATM deficiency, SLFN11 positive, POU2F3 positive by immunohistochemistry 2)
HR(homologous recombination) pathway gene mutation: BRCA 1/2, MRE11A, BLM, NBN, RAD50,
RAD52, RAD54L, RAD51, RAD51B, RAD51C, RAD51D, RECQL, RECQL4, RECQL5, RPA1, WRN etc.
3. Small cell lung cancer that has progressed during or after first-line therapy.
- The 1st line regimen must have contained platinum-based regimen with or without iCPI.
- Refractory to first-line chemotherapy or relapse within 6 months since the last dose
of first-line chemotherapy
- If the subject corresponds to sensitive relapse (relapse more than 6 months since the
last dose of first-line chemotherapy), she / he should receive second-line treatment
before entering the study 4. Subjects (male/female) must be > 18 years of age. 5.
Subjects must have normal organ and bone marrow function measured within 14 days prior
to administration of study treatment as defined below (transfusion allowed);
- Haemoglobin = 10.0 g/dL
- Absolute neutrophil count (ANC) = 1.5 x 109/L
- No features suggestive of MDS/AML on peripheral blood smear
- White blood cells (WBC) > 3x109/L
- Platelet count = 100 x 109/L
- Total bilirubin = 1.5 x institutional upper limit of normal (ULN)
- AST (SGOT)/ALT (SGPT) = 2.5 x institutional upper limit of normal unless liver
metastases are present in which case it must be = 5x ULN
- Serum creatinine = 1.5 x institutional upper limit of normal (ULN) or creatinine
clearance (CrCl) = 51 mL/min (Cockcroft-gault method).
A. CrCl = (140-age) x (weight (kg)) x (0.85 for female) i.
---------------------------------------------------------- A. (72 x serum creatinine
(mg/dL)) 6. ECOG performance status 0-2 subject must have a life expectancy = 16 weeks. 7.
Evidence of non-childbearing status for women of childbearing potential: negative urine or
serum pregnancy test within 28 days of study treatment, confirmed prior to treatment on day
1. Postmenopausal is defined as:
- Amenorrheic for 1 year or more following cessation of exogenous hormonal treatments,
- LH and FSH levels in the post-menopausal range for women under 50,
- radiation-induced oophorectomy with last menses > 1 year ago,
- chemotherapy-induced menopause with > 1-year interval since last menses,
- or surgical sterilization (bilateral oophorectomy or hysterectomy). 8. The subject is
willing and able to comply with the protocol for the duration of the study including
undergoing treatment and scheduled visits and examinations including follow up.
9. At least one lesion, not previously irradiated, that can be accurately measured at
baseline as = 10 mm in the longest diameter (except lymph nodes which must have short
axis = 15 mm) with computed tomography (CT) or magnetic resonance imaging (MRI) and
which is suitable for accurate repeated measurements.
10. Provision of informed consent for genetic research. 11. Male patients must use a
condom during treatment and for 6 months after the last dose when having sexual
intercourse with a pregnant woman or with a woman of childbearing potential. Female
partners of male patients and female patients should also use a highly effective form
of contraception ([see appendix A for acceptable methods]) for 6 months after the last
dose if they are of childbearing potential.
Exclusion Criteria:
1. Involvement in the planning and / or conduct of the study (applies to both
AstraZeneca/Roche staff and / or staff at the study sites)
2. Previous enrolment in the any of SUKSES umbrella trials.
3. Participation in another clinical study with an investigational product during the
last 2 weeks (or a longer period depending on the defined characteristics of the
agents used).
4. Any previous treatment with a PARP inhibitor not limited to olaparib.
5. More than two prior chemotherapy regimens for the treatment of small-cell lung cancer.
Pazopanib maintenance or immune checkpoint inhibitor (CTLA4, PD-1 or PD-L1 monoclonal
antibody) is not considered as line of treatment.
6. Subjects with second primary cancer stable without treatment for 2 years are eligible
for the trials. Adequately treated non-melanoma skin cancer, superficial urothelial
tumor, early gastric cancer, in-situ cancer of the cervix, thyroid cancer or other
solid tumours curatively treated with currently no evidence of disease is eligible for
the trial.
7. Subjects receiving any systemic chemotherapy, radiotherapy (except for palliative
reasons), within 2 weeks from the last dose prior to study treatment (or a longer
period depending on the defined characteristics of the agents used). The subject can
receive a stable dose of bisphosphonates or denosumab for bone metastases, before and
during the study as long as these were started at least 4 weeks prior to treatment
with study drug.
8. Concomitant use of known CYP3A4 inhibitors.
- Concomitant use of known strong CYP3A inhibitors (eg. itraconazole,
telithromycin, clarithromycin, protease inhibitors boosted with ritonavir or
cobicistat, indinavir, saquinavir, nelfinavir, boceprevir, telaprevir) or
moderate CYP3A inhibitors (eg. ciprofloxacin, erythromycin, diltiazem,
fluconazole, verapamil). The required washout period prior to starting <<select
olaparib or study treatment>> is 2 weeks
- Concomitant use of known strong (eg. phenobarbital, enzalutamide, phenytoin,
rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John's Wort
) or moderate CYP3A inducers (eg. bosentan, efavirenz, modafinil). The required
washout period prior to starting <<select olaparib or study treatment>> is 5
weeks for enzalutamide or phenobarbital and 3 weeks for other agents.
9. Persistent toxicities (> = CTCAE grade 2) with the exception of alopecia, caused by
previous cancer therapy.
10. Resting ECG with QTc > 470msec on 2 or more time points within a 24 hour period or
family history of long QT syndrome.
11. Subjects with symptomatic uncontrolled brain metastases. A scan to confirm the absence
of brain metastases is not required. The subject can receive a stable dose of
corticosteroids before and during the study as long as these were started at least 4
weeks prior to treatment. The subjects with brain metastases who is previously treated
and currently in stable status, no clinical symptom or image confirmed disease
progression, are eligible for the trial. The subjects with untreated asymptomatic
brain metastases is also allowed for the trial.
12. Major surgery within 14 days of starting study treatment or subjects not being
recovered from any effects of any major surgery
13. Subjects considered a poor medical risk due to a serious, uncontrolled medical
disorder, non-malignant systemic disease or active, uncontrolled infection. Examples
include, but are not limited to, uncontrolled major seizure discorder, uncontrolled
ventricular arrhythmia, recent (within 3 months) myocardial infarction, unstable
spinal cord compression which cause neurologic symptom (untreated and unstable for at
least 28 days prior to study entry), superior vena cava syndrome, extensive bilateral
lung disease on HRCT scan which cause respiratory distress or any psychiatric disorder
that prohibits obtaining informed consent.
14. Subjects unable to swallow orally administered medication and subjects with
gastrointestinal disorders likely to interfere with absorption of the study
medication.
15. Breastfeeding and pregnant women
16. Immunocompromised subject, e.g., subjects who are known to be serologically positive
for human immunodeficiency virus (HIV) and are receiving antiviral therapy.
17. Subjects with known active hepatic disease (i.e., Hepatitis B or C) due to the risk of
transmitting the infection through blood or other body fluids.
18. Subjects with a known hypersensitivity to olaparib or any of the excipients of the
product.
19. Subjects with uncontrolled seizures.
20. Exclusions related to bevacizumab
- Inadequately controlled hypertension (defined as systolic blood pressure >
150mmHg and/or diastolic blood pressure > 100 mmHg) identified during the
screening period and dose not resolved with resting or the treatment at the
following measurement. (Patient can be re-screened after appropriate manage for
lowering the blood pressure) Anti-hypertensive therapy to achieve these
parameters is allowable.
- Prior history of hypertensive crisis or hypertensive encephalopathy
- Significant vascular disease (e.g., aortic aneurysm requiring surgical repair or
recent peripheral arterial thrombosis) within 6 months prior to randomization
- History of hemoptysis (one-half teaspoon of bright red blood per episode) within
1 month prior to randomization
- Evidence of bleeding diathesis or coagulopathy (in the absence of therapeutic
anticoagulation)
- Current or recent (within 10 days of randomization) use of aspirin (325 mg/day)
or treatment with dipyramidole, ticlopidine, clopidogrel, and cilostazol
- Current use of full-dose oral or parenteral anticoagulants or thrombolytic agents
for therapeutic purposes that has not been stable for > 2 weeks prior to
randomization.
The use of full-dose oral or parenteral anticoagulants is permitted as long as the INR
or aPTT is within therapeutic limits (according to the medical standard of the
enrolling institution) and the subject has been on a stable dose of anticoagulants for
at least 2 weeks prior to randomization. The use of Direct Oral Anticoagulants is not
recommended due to increased bleeding risk.
Prophylactic anticoagulation for the patency of venous access devices is allowed,
provided the activity of the agent results in an INR < 1.5 x ULN and aPTT is within
normal limits within 14 days prior to randomization.
Prophylactic use of low-molecular-weight heparin (i.e., enoxaparin 40 mg/day) is
permitted.
- Core biopsy or other minor surgical procedure, excluding placement of a vascular
access device, within 7 days prior to the first dose of bevacizumab
- History of abdominal or tracheosphageal fistula or gastrointestinal perforation
within 6 months prior to randomization
- Clinical signs of gastrointestinal obstruction or requirement for routine
parenteral hydration, parenteral nutrition, or tube feeding
- Evidence of abdominal free air not explained by paracentesis or recent surgical
procedure
- Serious, non-healing wound, active ulcer, or untreated bone fracture
- Proteinuria, as demonstrated by urine dipstick or > 1.0 g of protein in a 24-hour
urine collection All subjects with = 2 + protein on dipstick urinalysis at
baseline must undergo a 24 hour urine collection and must demonstrate = 1 g of
protein in 24 hours.
- Known sensitivity to any component of bevacizumab
- Clear tumor infiltration into the thoracic great vessels is seen on imaging
- Clear cavitation of pulmonary lesions is seen on imaging
21. Previous allogenic bone marrow transplant or double umbilical cord blood
transplantation(dUCBT)
|
