| Eligibility |
Inclusion Criteria:
1. Male or female, aged = 18 years old
2. ECOG performance status of 0-2
3. Histologically or cytologically confirmed, Stage IIIB or IV NSCLC according to 8th
version of the International Association for the Study of Lung Cancer Staging Manual
in Thoracic Oncology, that is ALK+
4. Patients who have documented locally ALK rearrangement by one of the following
methods:
1. a positive result from the Vysis® ALK Break-Apart fluorescence in situ
hybridization (FISH) Probe Kit; or
2. IHC with VENTANA ALK (D5F3) CDx assay
5. No prior treatment for Stage IIIB or IV non-squamous NSCLC.
6. Having a life expectancy = 3 months
7. Patients who have received prior neo-adjuvant, adjuvant chemotherapy, radiotherapy, or
chemo-radiotherapy with curative intent for non-metastatic disease must have
experienced a treatment-free interval of at least 6 months from enrollment since the
last chemotherapy, radiotherapy, or chemo-radiotherapy.
8. Untreated or treated CNS metastases allowed, as long as asymptomatic and
neurologically stable
9. Patients with at least 1 measurable lesion, as defined by RECIST v1.1. Previously
irradiated lesions can only be considered as measurable if disease progression has
been unequivocally documented at that site since radiation and the previously
irradiated lesion is not the only site of disease.
10. Normal QT interval (QT) on screening ECG evaluation, defined as QT interval corrected
(Fridericia) (QTcF) of = 450 milliseconds (msec) in males of = 470 msec in females
11. Adequate hematologic and organ function defined by the following laboratory results
obtained within 14 days prior to enrollment:
- (ANC) Neutrophils = 1500 cells/µL without granulocyte colony-stimulating factor
support.
- Lymphocyte count = 500/µL.
- Platelet count = 75,000/µL without transfusion.
- Haemoglobin = 10.0 g/dL.
- INR or aPTT = 1.5 × upper limit of normal (ULN). This applies only to patients
who are not receiving therapeutic anticoagulation; patients receiving therapeutic
anticoagulation should be on a stable dose.
- AST, ALT, and alkaline phosphatase = 2.5 × ULN, with the following exceptions:
Patients with documented liver metastases: AST and/or ALT = 5 × ULN. Patients with
documented liver or bone metastases: alkaline phosphatase = 5 × ULN.
- Serum bilirubin = 1.5 × ULN. Patients with known Gilbert disease who have serum
bilirubin level < 3 × ULN may be enrolled.
- Serum creatinine = 1.5 × ULN
- Serum lipase and amylase = 1.5 × ULN
12. All patients are notified of the investigational nature of this study and signed a
written informed consent in accordance with institutional and national guidelines,
including the Declaration of Helsinki prior to any trial-related intervention.
13. Willingness and ability to comply with scheduled visits and study procedures
14. For female patients of childbearing potential, a negative pregnancy test must have
been documented prior to enrollment (within 14 days prior to enrollment)
15. For female patients of childbearing potential, agreement (by patient and/or partner)
to use a highly effective form(s) of contraception that results in a low failure rate
(< 1% per year) when used consistently and correctly, and to continue its use for 4
months after the last dose of brigatinib. No hormonal methods and preferably barrier
method always containing a spermicide, intrauterine device (IUD): intrauterine
hormone-releasing system (IUS), bilateral tubal occlusion, vasectomized partner (on
the understanding that this is the only one partner during the whole study duration),
and sexual abstinence.
16. For male patients with female partners of childbearing potential, agreement (by
patient and/or partner) to use a highly effective form(s) of contraception that
results in a low failure rate [< 1% per year] when used consistently and correctly,
and to continue its use for 4 months after the last dose of brigatinib. Male patients
should not donate sperm during this study and for at least 4 months after the last
dose of brigatinib.
17. Women who are not postmenopausal (= 12 months of non-therapy-induced amenorrhea) or
surgically sterile must have a negative serum pregnancy test result within 14 days
prior to enrollment.
Exclusion Criteria:
1. Patients with a known sensitizing mutation in the epidermal growth factor receptor
(EGFR) gene.
2. Patients with a known STK-1 Ligand alteration.
3. Patients with a known MDM2 amplification.
4. Patients with a known ROS1 translocations.
5. Patients that received any prior TKI, including ALK-targeted TKIs or any systemic
anticancer therapy for locally advanced or metastasic disease
6. Patients that have received chemotherapy or radiation within 14 days of first dose of
study drug, except stereotactic radiosurgery (SRS) or stereotactic body radiation
therapy (SBRT)
7. Symptomatic CNS metastases (parenchymal or leptomeningeal) that are neurologically
unstable or required an increasing dose of corticosteroids within 7 days prior to
first dose of study drug
8. Have current spinal cord compression (symptomatic or asymptomatic and detected by
radiographic imaging). Patients with leptomeningeal disease and without cord
compression is allowed.
9. Malignancies other than NSCLC within 3 years prior to enrollment (except for
adequately treated non-melanoma skin cancer, carcinoma in situ of the cervix,
localized prostate cancer treated surgically with curative intent, which were allowed
within 3 years)
10. Women who are pregnant, lactating, or intending to become pregnant during the study.
11. Patients that received monoclonal antibodies or had major surgery within 30 days of
the first dose of brigatinib (Day 1, Cycle1) or anticipation of need for a major
surgical procedure during the course of the study.
12. History of idiopathic pulmonary fibrosis, pulmonary interstitial disease, organizing
pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, idiopathic
pneumonitis, or evidence of active pneumonitis on screening chest CT scan.
13. Have uncontrolled hypertension. Patients with hypertension should be under treatment
on study entry to control blood pressure.
14. Positive test for HIV. All patients will be tested for HIV prior to inclusion into the
study; patients who test positive for HIV will be excluded from the clinical study.
15. Patients with active hepatitis B (chronic or acute; defined as having a positive
hepatitis B surface antigen [HBsAg] test at screening) or hepatitis C.
- Patients with past hepatitis B virus (HBV) infection or resolved HBV infection
(defined as the presence of hepatitis B core antibody [HBcAb] and absence of
HBsAg) are eligible only if they are negative for HBV DNA.
- Patients positive for hepatitis C virus (HCV) antibody are eligible only if PCR
is negative for HCV RNA.
16. Active tuberculosis.
17. Severe infections within 2 weeks prior to be included in the study, including but not
limited to hospitalization for complications of infection, bacteraemia, or severe
pneumonia.
18. Have significant, uncontrolled or active cardiovascular disease specifically including
but not restricted to:
- such as New York Heart Association cardiac disease (Class II or greater),
- myocardial infarction (MI) within 6 months prior to the first dose of study drug
- unstable angina within 6 months prior to the first dose of study drug
- congestive heart failure (CHF) within 6 months of the first dose of study drug
- history of clinically significant atrial arrhythmia (including clinically
significant bradyarrhythmia), as determined by the treating physician
- any history of ventricular arrhythmia
- cerebrovascular accident or transient ischemic attack within 6 months prior to
the first dose of study drug NOTE: Patients with known coronary artery disease,
congestive heart failure not meeting the above criteria, or left ventricular
ejection fraction < 50% must be on a stable medical regimen that is optimized in
the opinion of the treating physician, in consultation with a cardiologist if
appropriate.
19. Any other diseases, metabolic dysfunction, physical examination finding, or clinical
laboratory finding giving reasonable suspicion of a disease or condition that
contraindicates the use of an investigational drug or that may affect the
interpretation of the results or renders the patient at high risk from treatment
complications.
20. Patients with illnesses or conditions that interfere with their capacity to understand
follow and/or comply with study procedures.
21. History of or active significant GI bleeding or coagulopathy (in the absence of
therapeutic anticoagulation) within 3 months of the first dose of brigatinib
22. History of blood transfusion within 3 months of blood draw for translational research
23. Malabsorption syndrome or other GI illness that could affect oral absorption of the
study drug
24. Evidence of abdominal free air not explained by paracentesis or recent surgical
procedure.
25. Serious, non-healing wound, active ulcer, or untreated bone fracture
26. Known or suspected hypersensitivity to brigatinib or its excipients
27. Evidence of any other disorder or significant laboratory finding that makes the
patient undesirable to participate in the study
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