Ceritinib Plus Docetaxel in ALK-Negative, EGFR WT Advanced NSCLC

Status Active, not recruiting

Clinical Trial Summary

The main purpose of this study is to find out what effects (good and bad) ceritinib (Zykadia®) used in combination with docetaxel (Taxotere®) will have on participants and their cancer. The results will help to determine the best safe dose of the combination of the medications Ceritinib (Zykadia®) and docetaxel (Taxotere®) and to find out if this combination of drugs will help people that have this type of Non-small Cell Lung Cancer (NSCLC).

Clinical Trial Description

In this phase I/IB clinical trial, participants with non-small cell lung cancer (NSCLC) who have progressed on prior platinum-based chemotherapy (maximum number of prior distinct regimens = 2) and are anaplastic lymphoma kinase (ALK)-negative/epidermal growth factor receptor (EGFR) wild-type (WT) will receive a combination of ceritinib and docetaxel. Study rationale is that targeting ALK- and EGFR-negative lung tumors with ceritinib and microtubule inhibitors results in synergistic antitumor effects. Therefore, treatment with ceritinib and docetaxel is a rational combination. ;

Study Design

Related Conditions & MeSH terms

Carcinoma, Non-Small-Cell Lung
EGFR Negative Non-Small Cell Lung Cancer
Lung Cancer
Lung Neoplasms
Non-small Cell Lung Cancer
Non-small Cell Lung Cancer Metastatic
Non-small Cell Lung Cancer Stage IIIB
Stage IV Non-small Cell Lung Cancer

Clinical Trial Details

NCT number	NCT03611738
Study type	Interventional
Source	H. Lee Moffitt Cancer Center and Research Institute
Contact
Status	Active, not recruiting
Phase	Phase 1
Start date	February 1, 2019
Completion date	April 2025

View Details

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