Lung Cancer Clinical Trial
Official title:
Association of Bone and Metabolic Parameters With Overall Survival in Patients With Bone Metastases From Adenocarcinoma Lung Cancer (POUMOS)
Mortality due to non small cell lung cancers is the first cause of cancer death in men around
the world. Lung adenocarcinoma regularly induces bone metastases responsible for high
morbidity and impaired life quality. Overall survival of these patients is poor. Thus the
investigators aimed to identify if some bone and metabolic parameters were associated with
overall survival.
Patients and Methods POUMOS is a prospective cohort of patients suffering from adenocarcinoma
lung cancers with a first bone metastasis (stage IV). All patients have a bone biopsy with
molecular status characterization of the tumor for EGFR, KRAS, BRAF and ALK. Bone metastasis
localizations are obtained by bone scintigraphy or FDG-PET/CT. Whole body composition is
obtained by DEXA scan (Hologic®). The investigators assessed also fasting blood levels of
bone and metabolic biomarkers.
Survival analyses will be performed using a proportional hazard regression model.
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