Lung Cancer Clinical Trial
Official title:
A Single Arm, Open-label, Phase 2 Study to Assess the Efficacy and Safety of Lucitanib Given Orally as a Single Agent to Patients With Advanced/Metastatic Lung Cancer and FGF, VEGF, or PDGF Related Genetic Alterations
The purpose of this study is to determine whether lucitanib is safe and effective in the treatment of patients with advanced/metastatic lung cancer and fibroblast growth factor (FGF), vascular endothelial growth factor receptor (VEGF), or platelet derived growth factor (PDGF) related genetic alterations.
Lucitanib is an oral inhibitor of the tyrosine kinase activity of FGFR 1-3, VEGFR 1-3, and
PDGFR α/β. Lucitanib has demonstrated potent anti-tumor and anti-angiogenic activity in vitro
proliferation assays and in vivo using human tumor xenograft models, with a trend for
stronger efficacy in those with genomic aberrancies of FGF or PDGF. Abnormalities in the FGF,
VEGF, and PDGF-related genes are observed across lung cancer histologies.
The first in human trial of lucitanib demonstrated that daily lucitanib is clinically active
in patients with advanced solid tumors. Specifically, patients with FGFR1-amplification
appeared to derive particular benefit from lucitanib.
Based on these results, this study is designed to explore the safety and anti-tumor activity
of daily lucitanib in lung cancer patients with FGF, VEGF, and PDGF genetic alterations.
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