Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

Lung Cancer Clinical Trial

Official title:

Investigating the Feasibility of Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT01421784
• Other study ID #: STU 042011-034
• Status: Terminated
• Phase: N/A
• Start date: September 2011
• Est. completion date: November 25, 2015

Study information

• Verified date: June 2018
• Source: University of Texas Southwestern Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In this study, the researchers investigate the feasibility of using rapid cine MR imaging to provide both offline and online soft-tissue-based image guidance. Such images will provide a significantly more complete picture of the spatial and temporal changes in thoracic anatomy. This more complete information will lay the groundwork for better radiotherapy planning and dose delivery in the presence of respiratory motion.

Description:

Rapid MRI scans from Stage I-IV non-small-cell lung cancer (NSCLC) patients will be acquired. MR acquisition will be performed without extrinsically administered contrast, using a balanced turbo field echo (TFE) sequence and commercially available coils.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 17
• Est. completion date: November 25, 2015
• Est. primary completion date: November 25, 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 99 Years

Eligibility

Inclusion Criteria:

• AJCC Stage I, II, III or IV non-small-cell lung cancer to be treated using radiotherapy will be eligible for this study.

• Any types and amounts of prior therapy will be allowed for this study.

• Subjects must be greater than or equal to 18 years of age. There are no gender or ethnic restrictions.

• Ability to understand and the willingness to sign a written informed consent document.

• Able to tolerate supine position

• ECOG performance status of 3 or less

Exclusion Criteria:

• MRI-incompatible metallic implants, embedded metallic objects, implanted biomedical devices e.g., cardiac pacemakers

• Women who are pregnant or trying to get pregnant

• Pain in supine position

Related Conditions & MeSH terms

• Lung Cancer

Intervention

Other:
• cine MRI
Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

Locations

Country	Name	City	State
United States	UT Southwestern Medical Center	Dallas	Texas

Sponsors (1)

Lead Sponsor	Collaborator
University of Texas Southwestern Medical Center

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To measure time series of MRI imaging by the b-SSFP sequence.	To use fast acquisition sequences to obtain 2D and 3D cine MR images of moving and deforming lung tumors. The signal to noise ration (SNR) and spatiotemporal resolution of imaging sequences will be optimized into a format potentially useful for radiotherapy guidance.	6 weeks