Lung Cancer Clinical Trial
Official title:
Study of Epithelial Growth Factor Receptor Mutations in Tumor Specimens and Blood Samples From Patients With Non-Small Cell Lung Cancer Enrolled on Clinical Trial CASE-2507
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory
may help doctors learn more about changes that occur in DNA and RNA and identify biomarkers
related to cancer.
PURPOSE: This laboratory study is looking at biomarkers in tumor tissue and blood samples
from patients with non-small cell lung cancer.
OBJECTIVES:
Primary
- Identify mutations in epidermal growth factor receptor (EGFR) in non-small cell lung
cancer specimens from clinical trial CASE-2507.
- Investigate EGFR DNA copy-number changes.
- Determine abnormalities of other pathways, such as the c-MET and PI3K pathways as
potential mechanisms of resistance.
OUTLINE: This is a multicenter study.
DNA and RNA are extracted from tumor samples. Genomic DNA is analyzed using real-time PCR/
reverse transcriptase PCR analysis and/or FISH analysis in order to study resistance
mechanisms such as secondary EGFR mutations and the c-MET and PI3K pathways. RNA is analyzed
using TaqMan quantitative PCR in order to determine the copy number of EGFR expressed in
these tissues. Peripheral blood samples are used to isolate peripheral blood mononuclear
cells positive for epithelial cell adhesion molecule (EpCAM).
;
Observational Model: Case-Only, Time Perspective: Cross-Sectional
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