Lung Cancer Clinical Trial
Official title:
Identification and Validation of Molecular Markers in Lung Cancer
RATIONALE: Studying samples of tissue, blood, sputum, and urine from patients with lung
cancer and from healthy participants in the laboratory may help doctors learn more about
changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at biomarkers for lung cancer using tissue samples
from patients with lung cancer and from healthy participants.
OBJECTIVES:
- To identify new molecular abnormalities specific to the development of squamous cell
carcinoma of the lung.
- To determine the prevalence of candidate biomarkers in lung cancer progression.
- To determine the odds of developing lung cancer according to biomarker status in
preinvasive lesions.
- To determine the odds of developing lung cancer according to proteomic biomarker status
in the normal bronchial epithelium of high-risk patients.
OUTLINE: This is a multicenter study.
Tissue samples are collected at the time of fluorescence bronchoscopy for laboratory
biomarker studies. Blood, sputum, and urine samples are also collected. Gene and protein
expression studies are performed on the samples using comparative genomic hybridization
array, 3q oligonucleotide microarray, matrix-assisted laser desorption/ionization time of
flight mass spectrometry (MALDI-TOF), fluorescence in situ hybridization (FISH), and
immunohistochemistry (IHC).
Patients' medical records are reviewed to collect information about the patient's past
medical history and pertinent laboratory and radiography results.
Patients and healthy volunteers are followed annually via telephone or a mailed
questionnaire.
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