Lung Cancer Clinical Trial
Official title:
Isolation and Identification of Lung Cancer Precursor Cells From Malignant Pleural Effusion Specimens
RATIONALE: Studying samples of pleural fluid in the laboratory from patients with lung
cancer may help doctors identify early lung cancer cells. It may also help the study of lung
cancer in the future.
PURPOSE: This laboratory study is looking at malignant pleural effusion samples from
patients with primary lung cancer to see if early lung cancer cells can be identified.
OBJECTIVES:
- Isolate and identify lung cancer precursor cells in discarded pleural fluid specimens
obtained during routine thoracentesis procedures for the diagnosis and treatment of
malignant pleural effusions.
OUTLINE: Malignant pleural effusion specimens obtained from the Pathology Department at the
University Hospitals of Cleveland are analyzed using an immunomagnetic bead enrichment assay
to isolate cells of epithelial origin. The isolated cells are then stained with fluorescent
DNA binding dye, Hoechst 33342, and other markers (i.e., CD133, CD24/CD44) and sorted by
flow cytometry into progenitor and nonprogenitor subpopulations. The sorted subpopulations
are separated and examined functionally by in vitro and in vivo studies. Sphere culture
studies are also performed on the sorted subpopulations. The specimens may also be utilized
for transcriptional profiling studies, RNAi studies, and for the establishment of long-term
cultures and cell lines. DNA is also isolated and stored from tumor and nonepithelial normal
cell compartments for future genetic studies on known and unidentified genetic abnormalities
contributing to the development of lung cancer, such as EGFR, ErbB2, K-ras, and p53
mutational status.
;
Time Perspective: Retrospective
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