The Role of the Vagus Nerve in Tumor-to-Brain Communication in Lung Cancer Patients

Lung Cancer Clinical Trial

Official title:

Does the Vagus Nerve Play a Role in Tumor-to-Brain Communication? a Preliminary Study in Patients With Newly Diagnosed Lung Cancer

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00397124
• Other study ID #: vagusCTIL
• Status: Recruiting
• Phase: N/A
• First received: November 7, 2006
• Last updated: November 7, 2006
• Start date: April 2002

Study information

• Verified date: November 2006
• Source: Rambam Health Care Campus
• Contact: Alex Frenkel, Ph.D
• Phone: 972-4-8543009
• Email: a_frenkel[@]rambam.health.gov.il
• Is FDA regulated: No
• Health authority: Israel: Israeli Health Ministry Pharmaceutical Administration
• Study type: Interventional

Clinical Trial Summary

the aim of this study is to measure brain metabolism in patients with lung cancer.FDG uptake in the brain in patients with malignant tumors will be compared to the amount of tracer activity found in patients who have benign pulmonary process. if differences between the brain uptake of FDG in the two groups will be found, further assessment will be performed in order to evaluate if such differences could be attributed and specifically localized to the brain regions innervated by the vagus

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 40
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 35 Years to 70 Years

Eligibility

Inclusion Criteria:

• patients with SPN referred for routine whole body FDG-PET imaging

• patients with NSCLC and patients with no evidence of lung cancer on further follow up

Exclusion Criteria:

• patients with a clinical history of vagotomy, abdominal surgery. brain tumor, brain trauma or CVA. or those with a systemic inflammatory disease

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Lung Cancer
• Lung Neoplasms

Intervention

Device:
• PET/CT imaging

Locations

Country	Name	City	State
Israel	Rambam Medical Center	Haifa

Sponsors (1)

Lead Sponsor	Collaborator
Rambam Health Care Campus

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the impact of the imaging modality on patients management
Secondary	the impact of the imaging modality on patients management