Broccoli Sprout Extract in Preventing Lung Cancer in Smokers

Lung Cancer Clinical Trial

Official title: Evaluation of the Biological Effects of Broccoli Sprout Extract in Smokers

Status Completed

Clinical Trial Summary

RATIONALE: Chemoprevention is the use of certain drugs or substances to keep cancer from forming, growing, or coming back. The use of broccoli sprout extract may prevent lung cancer.

PURPOSE: This clinical trial is studying how well broccoli sprout extract works in preventing lung cancer in smokers.

Clinical Trial Description

OBJECTIVES:

Primary

• Evaluate the effect of broccoli sprout extract on levels of DNA adducts in participants who smoke.

• Determine the effectiveness of broccoli sprout extract in reducing tobacco-carcinogen induced DNA adducts in these participants.

Secondary

• Determine the effects of broccoli sprout extract on markers of the Nrf2 pathway in these participants.

• Determine the effectiveness of broccoli sprout extract, in increasing the activity of the Nrf2 pathway, in these participants.

• Evaluate the feasibility of using lymphocytes and buccal cells to monitor DNA adducts and changes in the Nrf2 pathway in these participants.

OUTLINE: Participants are stratified according to GST genotypic polymorphism (M1 vs T1).

Participants receive oral broccoli sprout extract daily for 3 weeks. Participants keep a daily diary of their eating and smoking habits for 3 weeks before, during, and for 3 weeks after study treatment. They must continue to smoke during the study, but are encouraged to quit after completing the study treatment.

PROJECTED ACCRUAL: A total of 70 participants will be accrued for this study. ;

Study Design

Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Lung Cancer
• Lung Neoplasms

• NCT number: NCT00255775
• Study type: Interventional
• Source: Sidney Kimmel Comprehensive Cancer Center
• Status: Completed
• Phase: N/A
• Start date: January 2005