Lung Cancer Clinical Trial
Official title:
Trans Retinoic Acid (Vesanoid) With Chemotherapy in Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating
patients who have stage IIIB or stage IV non-small cell lung cancer.
OBJECTIVES:
- Determine the response rate and duration of response to mitomycin, vinorelbine, and
cisplatin plus tretinoin in patients with stage IIIB or IV non-small cell lung cancer.
- Determine the toxicity of this treatment regimen in these patients.
- Determine survival of these patients with this treatment regimen.
OUTLINE: Patients receive tretinoin orally twice daily for 4 days starting days 1 and 8;
cisplatin IV over 2 hours and vinorelbine IV on days 1 and 8; and mitomycin IV (courses 1
and 3) on day 1. Treatment repeats every 3 weeks in the absence of disease progression or
unacceptable toxicity.
Patients are followed for survival.
PROJECTED ACCRUAL: At total of 15-46 patients will be accrued for this study.
;
Primary Purpose: Treatment
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