Lower Urinary Tract Symptoms Clinical Trial
Official title:
The Safety and Efficacy of Irreversible Electroporation Versus Standard Medication for the Treatment of Benign Prostatic Obstruction: a Randomized Controlled Trial
Irreversible electroporation (IRE) is a novel ablation modality using electric pulses to create nanoscale defects in the cell membrane. It has been verified to be safe on the treatment of prostate, lung, liver and kidney masses. The present is a randomized, controlled trial, with a main purpose of looking into the safety and feasibility of irreversible electroporation for patients with benign prostatic obstruction.
Benign prostatic obstruction (BPO) is the main reason to cause lower urinary tract symptoms
(LUTS) in aged male. Oral medications, such as,α1-adrenoceptor antagonist and 5α-reductase
inhibitors are the mainstay treatment options. However, some patients can not tolerate
long-term use, due to either side effects or limited efficacy. Though transurethral resection
or enucleation of prostate usually achieve significant symptom improvement, it's an end stage
procedure and it is only reserved for carefully selected patients.
The development of focal ablative therapy yields minimally invasive treatment option for
primary tumors such as the liver, lung, pancreas, kidney, and prostate. Among the novel
techniques are cryoablation, radiofrequency ablation (RFA), microwave ablation, and
high-intensity focused ultrasonography. Irreversible electroporation (IRE) is a one of the
ablation modalities using electric pulses to create nanoscale defects in the cell membrane.
IRE is not dependent on thermal energy and is therefore causing minimum damage to the blood
vessels, nerves and tissue architecture. The present is a randomized, controlled trial, with
a main purpose of looking into the safety and feasibility of irreversible electroporation for
patients with benign prostatic obstruction.
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