Perineural Methylene Blue Infusion in Lower Limb Amputation Surgery

Status Recruiting

Clinical Trial Summary

This prospective randomized controlled study will be conducted to evaluate the analgesic effect of continuous perineural infusion of methylene blue with bupivacaine on acute postoperative pain and to evaluate its preventive role against chronic phantom pain in patients undergoing lower limb amputation surgery

Clinical Trial Description

Post amputation pain remains an extremely challenging pain condition to treat, so the prevention of phantom pain is our goal to decrease its incidence. Methylene blue, an inhibitor of nitric oxide synthase and guanylate cyclase, has been widely applied for a variety of pain-related diseases due to its characteristic abilities, such as the blocking of pain transmission, antioxidant, and anti-inflammatory effects. Methylene blue can maintain local anesthesia for approximately 20 days so it can be used as a nerve block to relieve pain, especially refractory neuropathic pain. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05830630
Study type	Interventional
Source	Tanta University
Contact	Osama M Rehab, MD
Phone	00201095210806
Email	osamarehab@med.tanta.edu.eg
Status	Recruiting
Phase	N/A
Start date	May 1, 2023
Completion date	May 1, 2025

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