Low Back Pain Clinical Trial
Official title:
Genetic Predisposition for Reduced Back Muscle Strength and Back Muscle Endurance in Patients With Chronic Non-specific Low Back Pain
Patients with inflammatory back pain were shown to differ from healthy controls in genotype of the Angiotensin-converting enzyme (ACE), which regulates vasoconstriction/-dilatation. The aim of this study is to investigate whether genetic reduction of muscle perfusion might be a pathophysiological pathway of how genes influence chronic non-specific low back pain (LBP).
The following genes will be investigated:
- Insertions-/deletions-polymorphism of the angiotensin-converting enzyme (ACE-I/D gene
polymorphism; 3 genotypes: ACE-II, ACE-ID, ACE-DD).
- Anti-adhesive extracellular matrix protein Tenascin-C: gene polymorphism rs2104772
The goals of this study are to investigate whether these genotypes correlate with 1)
endurance of back muscles, 2) comorbidities such as asthma and diabetes and 3) the risk for
LBP as assessed by a LBP-classification tool.
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