Low Back Pain Clinical Trial
Official title:
Pharmacological Anxiolysis With Promethazine as an Adjunctive Therapy for Acute Low Back Pain in the Adult Emergency Department
Acute low back pain is a common cause for emergency department visits. Controversy remains regarding the optimal medication for acute low back pain relief. The investigators hypothesized that administration of pharmacological anxiolysis in addition to analgesia will improve pain relief and patient management in the emergency department.
Acute low back pain is a common problem in the emergency department and pain relief is
usually the first step in patients' management. Numerous medication options are available
for acute LBP relief,each class of medication has its associated benefits and
harms.Controversy remains regarding the optimal analgesic treatment.Anxiety has been found
to be a predictive factor of pain intensity in patients with acute low back pain and
anxiolysis by non-pharmacological measures has been shown to have a positive effect on pain
management in the ED setting.
Promethazine is a first-generation H1 receptor antagonist of the phenothiazine chemical
class used commonly as an antihistamine antiemetic. It has a strong anxiolytic-sedative
effect and its safety and efficacy in managing anxiety related to medical procedures is well
documented.It may be reasonable to assume that pharmacological anxiolysis with promethazine
may assist in alleviation of acute pain in the strenuous environment of the ED.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
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