Long QT Syndrome Clinical Trial
Official title:
Hydroxyzine and Risk of Prolongation of QT Interval
On 04/30/2015, ANSM (the National Security Agency of Medicines and Health Products) shared
an information for general practicioners, pediatricians, anesthesiologists, dermatologists,
geriatricians, psychiatrists, community pharmacists and hospital about using hydroxyzine and
the associated risk of QT prolongation on the electrocardiogram.
Drugs containing hydroxyzine (the best known and most used is the Atarax®) are used in
France in various indications including the treatment of minor manifestations of anxiety,
premedication with general anesthesia and the symptomatic treatment of urticaria.
A prolonged QT interval is a known risk factor for occurrence of torsades de pointes which
can cause sudden death. We distinguish congenital and acquired long QT interval. The main
cause of acquired long QT interval is a drug inhibition of the HERG potassium channel 1.
Many drugs have been reported to cause sudden death by prolongation of QT interval and
occurrence of torsades de pointes (macrolides, anti -arythmics, some psychotropic ...) The
molecules based on hydroxyzine are known to be at risk of prolongation of QT interval in an
experimental point of view but is not clearly identified in daily clinical practice.
Pharmacology unit of Caen was the first to publish a case of QT prolongation under
hydroxyzine . Through this publication, associated with other clinical data, hydroxyzine has
been added to the list of drugs that can induce QT prolongation .
Despite these recent recommendations, it does not seem that hydroxyzine prescriptions were
changed daily and therefore the risk of QT prolongation persists. We therefore propose the
study of the impact of hydroxyzine on the QT interval measured on the electrocardiogram in
patients hospitalized at the University Hospital of Caen.
n/a
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04169100 -
Novel Form of Acquired Long QT Syndrome
|
Phase 4 | |
| Completed |
NCT01648205 -
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients
|
Phase 2 | |
| Recruiting |
NCT06087367 -
Building of a Diagnostic/Prognostic Database for Human ERG Variant Effects
|
||
| Recruiting |
NCT04675788 -
Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening
|
Phase 4 | |
| Completed |
NCT05759962 -
Phase 1 Study of LQT-1213 in Healthy Adults
|
Phase 1 | |
| Enrolling by invitation |
NCT05903313 -
A Study to Evaluate Accuracy and Validity of the Chang Gung ECG Abnormality Detection Software
|
||
| Terminated |
NCT02439645 -
A Registry to Determine the Clinical and Genetic Risk Factors for Torsade De Pointes
|
||
| Recruiting |
NCT00221832 -
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases
|
N/A | |
| Completed |
NCT04706104 -
QT Measurement Techniques and Anesthesia Management
|
||
| Recruiting |
NCT04336644 -
Continuous Versus Intermittent cARdiac Electrical moNitorinG
|
N/A | |
| Completed |
NCT02876380 -
Prospective Identification of Long QT Syndrome in Fetal Life
|
||
| Completed |
NCT02425189 -
The Canadian National Long QT Syndrome Registry
|
||
| Completed |
NCT00399412 -
ECG Signal Collection From Long QT Syndrome, Wide QRS Complexes, Heart Failure, and Cardiac Resynchronization Patients
|
N/A | |
| Completed |
NCT02513940 -
Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes
|
Phase 4 | |
| Completed |
NCT02441829 -
Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Renal Function
|
Phase 1 | |
| Completed |
NCT03182777 -
Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies
|
N/A | |
| Completed |
NCT01849003 -
Study of the Effect of GS-6615 in Subjects With LQT-3
|
Phase 1 | |
| Completed |
NCT00316459 -
Study Evaluating the Effects of Multiple Oral Doses of ERB-041 on Cardiac Repolarization in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT00292032 -
Registry of Unexplained Cardiac Arrest
|
||
| Recruiting |
NCT05348564 -
Comparing Direct vs Indirect Methods for Cascade Screening
|
N/A |