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Clinical Trial Summary

This is a first in human study in patients with advanced or metastatic solid tumors known to have an MTAP deletion. The first part of the study is an open-label, dose escalation and the second part is an open label dose expansion in specific MTAP-deleted tumor types. The study drug, TNG908, is a selective PRMT5 inhibitor administered orally. The study is planned to treat up to 192 participants.


Clinical Trial Description

This is a Phase 1/2 multi-center, open label study in solid tumor patients (including glioblastoma) who have a confirmed homozygous MTAP deletion in their tumor. The Phase 1 portion is a dose escalation study of oral TNG908 in patients with confirmed MTAP-deleted solid tumors. In Phase 2, 6 expansion arms defined by confirmed MTAP-deleted tumor types will enroll in parallel at the RP2D of TNG908. In both parts of the study participants who tolerate the drug may continue treatment until disease progression. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05275478
Study type Interventional
Source Tango Therapeutics, Inc.
Contact Tango Clinical Trials
Phone (857) 320-4899
Email clinicaltrials@tangotx.com
Status Recruiting
Phase Phase 1/Phase 2
Start date March 23, 2022
Completion date September 2025

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