Living Renal Donor Clinical Trial
Official title:
Comprehensive Morphological and Functional Assessment of Living Renal Donor With Magnetic Resonance Imaging With Comparison to Computed Tomographic Angiography and Renal Scintigraphy
Accurate preoperative evaluation of a potential living renal donor's anatomy, vasculature
and function is crucial to ensure optimal outcomes for both kidney donor and recipient in
transplantation.
Currently abdominal ultrasound and spiral CT angiography are used to evaluate renal anatomy
and vascular status, and renal scintigraphy to evaluate renal function. This imaging
protocol exposes this relatively young and healthy population to a high radiation dose and
potentially nephrotoxic contrast agents.
The investigators hypothesize that a single MR-based examination in the preoperative
evaluation of potential kidney donor is a faster, safer, more cost effective and as accurate
as the current multiple imaging work-up protocol.
An accurate preoperative assessment of the renal donor is essential to minimize the risks
for the donor & optimize the results for the recipient.
The current preoperative assessment includes Ultrasound, CT & Renal Scintigraphy. The latter
two tests subjects the patient to the risk of a high radiation dose. Moreover, the use of
iodinated contrast media during CT angiography may increase the risk of renal & systemic
toxicity.
MRI can be a "one-stop shop" modality for preoperative assessment of living kidney donors.
MRI also eliminates radiation exposure and the injection of potentially nephrotoxic
iodinated contrast material.
The purpose of this study is to test the feasibility and evaluate the accuracy of a single
MR-based examination, allowing for the comprehensive assessment of renal anatomy, function
and vascular status in potential live kidney donors.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT00460889 -
Renal Donor Comparison of Outcomes: Hand Assist Versus Laparoscopic Nephrectomy
|
N/A |