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NCT06209775 Clinical Trial

Impact of Perioperative Body Composition Abnormalities on Patient Outcomes After Liver Transplantation

Liver Transplantation Clinical Trial

Official title:
Impact of Perioperative Body Composition Abnormalities on Patient Outcomes After Liver Transplantation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT06209775
Other study ID # CT2023-ZJU-OBS5
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2015
Est. completion date December 31, 2022

Study information
Verified date January 2024
Source Zhejiang University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Accumulating evidence suggests the prognostic significance of body composition in chronic diseases and neoplastic diseases. CT imaging-based body composition abnormalities are significantly associated with post-LT adverse outcomes including decreased quality of life (QOL), impaired graft regeneration and mortality. However, the perioperative changes in body composition and their potential clinical implications remain unexplored. The objective of this study is to systematically explore and clarify the correlation between body composition and the prognosis of liver transplant patients through dynamic peri-transplant mornitoring.

Recruitment information / eligibility
Status Completed
Enrollment 996
Est. completion date December 31, 2022
Est. primary completion date December 31, 2022
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Adult patients undergoing deceased donor liver transplantation (DDLT) for the first time. Exclusion Criteria: - Pediatric transplants - Re-transplants - Multi-organ transplants - Liver cancer patients with macrovascular invasion or distant metastasis - Patients who died within 30 days after transplantation

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (4)
Lead Sponsor Collaborator
Zhejiang University First Affiliated Hospital of Zhejiang University, Shulan (Hangzhou) Hospital, The Affiliated Hospital of Qingdao University

Outcome
Type Measure Description Time frame Safety issue
Primary Postoperative mortality 2015.1.1-2022.12.31
Primary Postoperative recurrence of liver cancer 2015.1.1-2022.12.31
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