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NCT05448339 Clinical Trial

Tumor Feeding Vessels Deprivation Combined With Tyrosine Kinase Inhibitor in Liver Transplantation

Liver Transplantation Clinical Trial

Official title:
The Value of Tumor Feeding Vessels Deprivation Combined With Tyrosine Kinase Inhibitor in Liver Transplantation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05448339
Other study ID # SHLTQC-5
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2013
Est. completion date January 1, 2024

Study information
Verified date January 2024
Source Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To investigate the value of tumor feeding vessels deprivation combined with tyrosine kinase inhibitor in liver transplantation. Patients are enrolled into two groups according to the downstaging therapy they undergo before transplantion.

Recruitment information / eligibility
Status Completed
Enrollment 197
Est. completion date January 1, 2024
Est. primary completion date December 31, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years to 65 Years
Eligibility (1) age =18 years; (2) exceeding UCSF criteria; (3) absence of vascular invasion, nodal involvement, or extrahepatic metastases; (4) receiving TACE treatment or LTFVD treatment for downstaging purposes.

Study Design

Related Conditions & MeSH terms

Intervention

Combination Product:
• PVHA or TACE
PVHA or TACE

Locations
Country Name City State
China Shanghai General Hospital Shanghai Shanghai

Sponsors (1)
Lead Sponsor Collaborator
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Underwent LT Underwent LT January 2013 and December 2020
Primary Successful downstaging Successful downstaging January 2013 and December 2020
Secondary AFP reduction of patients AFP reduction of patients January 2013 and December 2020
Secondary Survival time of patients Survival time of patients January 2013 and December 2020
Secondary Recurrence of patients Recurrence of patients January 2013 and December 2020
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