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NCT05277623 Clinical Trial

Effect of Mannitol on Postreperfusion Syndrome During Living Donor Liver Transplant

Liver Transplant Disorder Clinical Trial

Official title:
Effect of Mannitol on Postreperfusion Syndrome During Living Donor Liver Transplant: a Randomized Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05277623
Other study ID # R 42/ 2022
Secondary ID
Status Completed
Phase Early Phase 1
First received
Last updated
Start date April 4, 2022
Est. completion date December 10, 2022

Study information
Verified date January 2023
Source Ain Shams University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Postreperfusion syndrome during living liver transplants remains a serious concern for transplant anesthesiologists. This syndrome is responsible for decreases in systemic blood pressure, systemic vascular resistance, and cardiac output and can even lead to cardiac arrest. Delayed graft function and primary graft nonfunction are closely related to postreperfusion syndrome (Therefore, attenuating the syndrome during anesthesia is of great importance.

Recruitment information / eligibility
Status Completed
Enrollment 60
Est. completion date December 10, 2022
Est. primary completion date November 5, 2022
Accepts healthy volunteers No
Gender All
Age group 16 Years and older
Eligibility Inclusion Criteria: - patients with end-stage liver disease who will undergo living donor transplantation. Exclusion Criteria: - Patients with a history of portopulmonary hypertension. - Hepatopulmonary syndrome. - Cirrhotic cardiomyopathy. - Hepatorenal syndrome types 1 and 2.

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Mannitol
During the anhepatic phase, the patients in the mannitol group (30) will receive 1 g/kg
Other:
• 0.9% normal saline
the same amount of 0.9% normal saline

Locations
Country Name City State
Egypt Medicine Ain Shams University Cairo

Sponsors (1)
Lead Sponsor Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary mean arterial blood pressure postreperfusion mean blood pressure one hour after reperfusion
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