Perioperative Analgesia by ESP Catheter on Recipient for Liver Transplantation

Liver Transplant Disorder Clinical Trial

— ESPLIVERRec  

Official title:

Does Bilateral Continuous Peri Operative Erector Spinae Plane (ESP) Block Improve the Enhanced Recovery Program After Liver Transplantation in Recipient Patient

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT04584151
• Other study ID #: VINMEC LT REC
• Status: Terminated
• Phase: N/A
• Start date: November 1, 2020
• Est. completion date: August 14, 2023

Study information

• Verified date: August 2023
• Source: Vinmec Healthcare System
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Enhanced recovery after surgery (ERAS) programs were developed by Prof Henrik Kehlet in Denmark to reduce the hospitalization and improve the surgical outcomes. In these programs pain relief by regional analgesia techniques are highly recommended to reduced as much as possible the opioids used with their side effects. This program was created for colo-rectal surgeries and extended to other surgeries. In Liver transplants different programs has been described top reduce the use of peri-operative opioids but no with the ESP Animal and molecular studies in chronic pain showed the activation of glial cells, Monocytes and lymphocite K similar to the reaction during severe septis with immune reaction and toll like receptor activation. Regional anaesthesia analgesia is blocking this activation of Tool Like Receptors (TLR4) One of the discharge criteria after liver transplantation is the equilibrium of plasmatic cyclosporin Our hypothesis is with regional analgesia to avoid any immune disorder due to pain and reach earlier the discharge criteria than with standard analgesia Improve the quality of recovery and reduce the hospitalization stay after liver transplantation

Description:

1. Goals:

Compare quality of analgesia and quality of recovery between bilateral ESP bilateral catheters versus Opioid analgesia in adult included in an enhanced recovery program after liver transplantation Show that the addition of peri-operative regional analgesia improves the enhanced recovery program after open liver transplant in recipient patient .

2. Methodology:

•Selection criteria: Age > 18 years old Have a clinical indication for Liver transplantation ( list for surgeries listed in full proposal) Agree to participate in the trial

•Exclusion criteria: Use of chronic opioid Contra-indication tom perform ESP catheter (Infection near puncture point, Severe thoracic scoliosis, allergy to local anaesthetics) A diagnosis of a chronic pain condition Depression or other psychiatric diagnosis

• Study design: Prospective Randomized Controlled Trial.

Patients who agree to join the study will be randomized into 2 groups:

Group 1 (Control group): standard of care in Liver donation : Intra operative analgesia by Opioid Sufentanil and post operative analgesia by Patient Controlled analgesia (PCA) opioid morphine Group 2 (treatment group): Standard peri-operative analgesia for Liver donation in our hospital since we use regional anaesthesia as first line treatment for peri operative analgesia Bilateral ESP catheters with continuous regional analgesia by infusion of local anaesthetic (Ropivacaine)

Sample size: We expected to reduce the length of stay for liver receipt from 11 ± 2.22 days in ERAS group to 8 ± 2.22 days in the ESP group The sample size of 10 patients per group is required to detect such changes assuming a confidence interval of 95% with a power of 90% and alpha = 0.05. Considering 20% of drop-out, the total sample size is 40 patients (20 patients each group)

3. Project outcomes:

• Primary outcomes Length of stay in Hospital Our estimation based on our previous studies for ESP and the literature for ERAS programs in open heart surgeries

• Secondary outcomes Time to extubation Duration of stay in ICU Time to 1st mobilisation Opioid consumption in relation with VAS Rest and mobilization

Patient satisfaction:

• Quality of recovery scoring 15 items (QOR 15)

• Pain at 1 month rest and mobilization + Quality of Life scoring (QOL36)

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 11
• Est. completion date: August 14, 2023
• Est. primary completion date: August 14, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• age clinical indication for liver transplantation agree to participate and signed consent

Exclusion Criteria:

• Use of chronic opioid contra indication to perform ESP cathters Diagnosis of a chronic pain condition except liver disease Psychiatric or depression disorder allergy to local anesthetics

Related Conditions & MeSH terms

• Liver Transplant Disorder

Intervention

Procedure:
• regional analgesia
Insertion of bilateral ESP catheters

Locations

Country	Name	City	State
Vietnam	VinMec INternational hopspital	Hanoi
Vietnam	VinMec INternational hospital	Hanoi

Sponsors (1)

Lead Sponsor	Collaborator
Vinmec Healthcare System

Country where clinical trial is conducted

Vietnam, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Length of stay in hospital	Time to reach the criteria of hospital discharge after liver transplantation	up to 30 day
Secondary	Duration of stay in Intensive care Unit (ICU)	Time to reach the criteria of ICU discharge after liver transplantation	up to 72 hours
Secondary	Quality of recovery: score	Score on 15 criteria for quality of recovery from 0= very poor to 150 = excellent	up to 30 days