co2 Gap and co2/o2 Ratio in Liver Transplant Patients

Liver Transplantation Clinical Trial

— co2gap  

Official title:

Use of the Venoarterial Carbon Dioxide Gap and Arteriovenous Oxygen Content to Guide the Resuscitation in the Liver Transplant Patients

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03374579
• Other study ID #: N-60-2017
• Status: Recruiting
• Phase: N/A
• First received: December 11, 2017
• Last updated: March 27, 2018
• Start date: June 12, 2017
• Est. completion date: September 12, 2018

Study information

• Verified date: March 2018
• Source: Kasr El Aini Hospital
• Contact: Ahmed m Mukhtar, Professor
• Phone: +0220111420844
• Email: Ahmed.mukhtar[@]kasralainy.edu.eg
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

finding surrogate to co to trace the effect of preload challenge would make the test more applicable without the need of advanced hemodynamic monitors,suggested that co2 gap can be used to detect FR after mini fluid challenge and fluid bolts .

Description:

use of carbon dioxide gap and arterio venous oxygen content to trace the effect of preload challenge by giving via a specific venous line , first 150 ml is infused over one minute, after stroke volume at one minute measure the remaining 350 ml is infused over 14 minutes at constant rate , the fluid challenge performed with albumin 5% , fluid responsiveness is an increase in stroke volume by 15% after infusion of 500ml albumin 5%.

Objectives is to investigate the ability of VA-co2 gap and gap/ ratio to predict the hemodynamic response to mini fluid challenge, and to compare the validity of VA-co2 gap and gap/ratio with svo2 for prediction of fluid responsiveness.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 40
• Est. completion date: September 12, 2018
• Est. primary completion date: May 12, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• patients post liver transplantation

• serum lactate >2mmol/L

Exclusion Criteria:

• age less than 18 years

• patients with fulminant liver failure.

Related Conditions & MeSH terms

• Liver Transplantation

Intervention

Diagnostic Test:
• Fluid challenge
Fluid challenge and measure change in co2 gap

Locations

Country	Name	City	State
Egypt	Cairo University Medical School	Cairo
Egypt	Kasralainy hospital	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Kasr El Aini Hospital

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	co2gap	Difference between arterial and venous co2 gap	30 minuets after fluid bolus
Secondary	Stroke volume	Stroke volume assessed by cardiometry	Baseline 30 minutes after Icu admission, 1 minutes after mini fluid challenge , 30 minutes after fluid bolus