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Influence of Genetic Polymorphism of Donor on Tacrolimus Concentration in Liver Transplant

Liver Transplantation Clinical Trial

Official title:
The Influence of ABCB1、CYP3A4、CYP3A5、POR Genetic Polymorphism of Donor on Tacrolimus Blood Concentration in Liver Transplant Patients

Clinical Trial Summary

To study the influence of donor's ABCB1、CYP3A4、CYP3A5、POR genetic polymorphism on tacrolimus blood concentration in liver transplant recipients.

Clinical Trial Description

This study will start with a retrospective data analysis. The investigators will use the electronic databases of National Taiwan University Hospital to identify patients who underwent liver transplantation, received tacrolimus and were still followed up at the outpatient clinic. Inclusion and exclusion criteria will be applied to screen appropriate participants, and find their donors. And analyze the effect of genetic polymorphism (ABCB1、CYP3A4、CYP3A5、POR) of donors, including other factors of recipients, on the dose normalized trough concentration of tacrolimus. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03140462
Study type Observational
Source National Taiwan University Hospital
Contact
Status Completed
Phase
Start date May 21, 2017
Completion date December 31, 2020
View Details
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