Eating Behaviour and Gustatory Sensitivity Before and After Liver Transplant in Cirrhotic Patients

Liver Transplant Clinical Trial

— GREFFE  

Official title:

Eating Behaviour and Gustatory Sensitivity Before and After Liver Transplant in Cirrhotic Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02859506
• Other study ID #: BRONDEL INRA 2013
• Status: Completed
• Phase: N/A
• Start date: July 3, 2015
• Est. completion date: December 13, 2019

Study information

• Verified date: February 2024
• Source: Centre Hospitalier Universitaire Dijon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Today, we know that olfactogustatory alterations occur in cirrhotic patients before the liver transplant but no study has been conducted to show eventual disturbances after the transplantation able to explain modifications in eating behaviour. In parallel, the metabolic status, itself dependent on liver metabolism, influences food preferences and is modified after the transplantation as the liver recovers its ability to store glycogen, but is not able to inform the brain as the afferent nerve impulses have been suppressed. The innovative aspect of this project is to provide information on the importance of the liver in the regulation of energy homeostasis.

The results of this study will improve our understanding of eating behaviour and olfactogustatory sensitivity and allow us to orient liver transplant patients towards appropriate diets.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 73
• Est. completion date: December 13, 2019
• Est. primary completion date: December 13, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• persons who have provided written informed consent

• persons aged between 18 and 70 years

• persons waiting for a liver transplantation (group LT)

• persons with stable liver damage

• persons waiting for a kidney transplantation (KT)

• healthy subjects (control group) no known disease

Exclusion Criteria:

• persons without national health insurance cover

• persons with chronic infection,

• persons with acute infection,

• persons with progressive cancer,

• persons with an antibiotic treatment,

• persons who drink alcohol,

• pregnant or breast-feeding women,

• persons with an aversion to the foods proposed in the study,

• persons taking treatments known to interfere with gustatory and olfactory performance,

• adults under guardianship

Related Conditions & MeSH terms

• Eating Behaviour
• Hypersensitivity
• Liver Transplant

Intervention

Other:
• Respiratory quotient

• Olfactory liking

Locations

Country	Name	City	State
France	Centre Hospitalier Universitaire	Dijon

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire Dijon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in respiratory quotient (RQ) by indirect calorimetry compared with baseline values		At month 0, month 3, month 9 and month 15
Primary	Change in olfactory liking compared with baseline values by questionnaire		At month 0, month 3, month 9 and month 15